A novel integrated platform enabling simultaneous microextraction and chemical analysis on-chip

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Santigosa-Murillo, Elia (author)

A novel integrated platform enabling simultaneous microextraction and chemical analysis on-chip

Article/chapterEnglish2023

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2023
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LIBRIS-ID:oai:DiVA.org:su-229795
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-229795URI
https://doi.org/10.1016/j.microc.2023.109044DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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The nature and size of biological, pharmaceutical or environmental analytes complicates their extraction and detection outside of laboratories and near the site of interest by the current chromatographic methods because they require the combination of bulky extraction and detection methods. In order to solve this inefficient centralized control, a ground-breaking and miniaturized proof of concept platform is developed in this work. The platform integrates for the very first time an electro-membrane extraction process and an accurate analyte quantification method in the same device, by using electrochemical impedance spectroscopy (EIS) as analytical technique. The microfluidic flow cell, including the microfluidic components, is fabricated in polymeric materials by rapid prototyping techniques. It comprises a four-electrode platinum thin-film chip that enables the control of the microextraction and the full characterization of the process, i.e., extraction efficiency determination, at the same time. The microfluidic system has been simulated by using computational tools, enabling an accurate prediction of the effect of the different experimental conditions in the microextraction efficiency. The platform has been validated in the microextraction of the nonsteroidal anti-inflammatory drug ketoprofen in a range from 0.5 ppm to 6 ppm. The predicted microextraction efficiency values obtained by EIS were compared with those calculated from the high-performance liquid chromatography coupled with a diode array detector (HPLC-DAD), showing an excellent agreement. This validates the high potential of this integrated and miniaturized platform for the simultaneous extraction by electro-membrane and also the analysis within the platform, solving one of the of most important limitations of current systems.

Subject headings and genre

NATURVETENSKAP Kemi Analytisk kemi hsv//swe
NATURAL SCIENCES Chemical Sciences Analytical Chemistry hsv//eng
Electromembrane microextraction
Electrochemical impedance spectroscopy detection
Biological
pharmaceutical or environmental analytes detection
Thin-film microelectrodes

Added entries (persons, corporate bodies, meetings, titles ...)

Moreno, Alexandre (author)
Ramos-Payan, Maria (author)
Rios, Juan Manuel (author)
Munoz-Berbel, Xavier (author)
Munoz, Maria (author)
Giménez-Gómez, Pablo,1984-Stockholms universitet,Institutionen för material- och miljökemi (MMK),Instituto de Microelectrónica de Barcelona (IMB-CNM, CSIC), Barcelona, Spain(Swepub:su)pagi6142 (author)
Stockholms universitetInstitutionen för material- och miljökemi (MMK) (creator_code:org_t)

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In:Microchemical journal (Print)1930026-265X1095-9149

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NATURAL SCIENCES: NATURAL SCIENCES; and Chemical Science ...; and Analytical Chemi ...

Articles in the publication: Microchemical jo ...

By the university: Stockholm University

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