Search: onr:"swepub:oai:DiVA.org:su-230230" >
investigating cell ...
investigating cell type changes in schizophrenia with spatially-resolved transcriptomics
-
- hower, lee (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
- langseth, christoffer mattsson (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
- Valiukonytė, milda (author)
- karolinska institutet, sweden
-
show more...
-
gyllborg, daniel (author)
-
- memic, fatima (author)
- karolinska institutet, sweden
-
- Markus M., Hilscher (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
- Hjerling-Leffler, Jens (author)
- karonlinska institutet, sweden
-
- nilsson, mats (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
show less...
-
(creator_code:org_t)
- English.
- Related links:
-
https://urn.kb.se/re...
Abstract
Subject headings
Close
- Schizophrenia is a heritable and genetically complex disorder with poorly understood aetiology. Previous study from our lab has shown that this disorder could affect a limited number of cell types in the brain1. Here, we build on these findings and present the first spatially-resolved transcriptomics study of schizophrenia with a large number of samples (17 in total). By comparing spatial cell type distributions in diseased and healthy prefrontal cortices, we discover that certain non-neuronal cell types change their co-localization patterns
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- in situ sequencing
- cell typing
- schizophrenia
- in situ hybridization
- biokemi
- Biochemistry
Publication and Content Type
- pop (subject category)
- ovr (subject category)
To the university's database