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investigating cell type changes in schizophrenia with spatially-resolved transcriptomics

hower, lee (author)
Stockholms universitet,Institutionen för biokemi och biofysik
langseth, christoffer mattsson (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Valiukonytė, milda (author)
karolinska institutet, sweden
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gyllborg, daniel (author)
memic, fatima (author)
karolinska institutet, sweden
Markus M., Hilscher (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Hjerling-Leffler, Jens (author)
karonlinska institutet, sweden
nilsson, mats (author)
Stockholms universitet,Institutionen för biokemi och biofysik
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 (creator_code:org_t)
English.
  • Other publication (pop. science, debate, etc.)
Abstract Subject headings
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  • Schizophrenia is a heritable and genetically complex disorder with poorly understood aetiology. Previous study from our lab has shown that this disorder could affect a limited number of cell types in the brain1. Here, we build on these findings and present the first spatially-resolved transcriptomics study of schizophrenia with a large number of samples (17 in total). By comparing spatial cell type distributions in diseased and healthy prefrontal cortices, we discover that certain non-neuronal cell types change their co-localization patterns

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

Keyword

in situ sequencing
cell typing
schizophrenia
in situ hybridization
biokemi
Biochemistry

Publication and Content Type

pop (subject category)
ovr (subject category)

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