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Educational attainm...
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Howe, Laurence J.
(author)
Educational attainment, health outcomes and mortality : a within-sibship Mendelian randomization study
- Article/chapterEnglish2023
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LIBRIS-ID:oai:DiVA.org:su-230263
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-230263URI
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https://doi.org/10.1093/ije/dyad079DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background Previous Mendelian randomization (MR) studies using population samples (population MR) have provided evidence for beneficial effects of educational attainment on health outcomes in adulthood. However, estimates from these studies may have been susceptible to bias from population stratification, assortative mating and indirect genetic effects due to unadjusted parental genotypes. MR using genetic association estimates derived from within-sibship models (within-sibship MR) can avoid these potential biases because genetic differences between siblings are due to random segregation at meiosis. Methods Applying both population and within-sibship MR, we estimated the effects of genetic liability to educational attainment on body mass index (BMI), cigarette smoking, systolic blood pressure (SBP) and all-cause mortality. MR analyses used individual-level data on 72 932 siblings from UK Biobank and the Norwegian HUNT study, and summary-level data from a within-sibship Genome-wide Association Study including >140 000 individuals. Results Both population and within-sibship MR estimates provided evidence that educational attainment decreased BMI, cigarette smoking and SBP. Genetic variant-outcome associations attenuated in the within-sibship model, but genetic variant-educational attainment associations also attenuated to a similar extent. Thus, within-sibship and population MR estimates were largely consistent. The within-sibship MR estimate of education on mortality was imprecise but consistent with a putative effect. Conclusions These results provide evidence of beneficial individual-level effects of education (or liability to education) on adulthood health, independently of potential demographic and family-level confounders.
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Rasheed, Humaira
(author)
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Jones, Paul R.
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Boomsma, Dorret
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Evans, David M.
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Giannelis, Alexandros
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Hayward, Caroline
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Hopper, John L.
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Hughes, Amanda
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Lahtinen, Hannu
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Li, Shuai
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Lind, Penelope A.
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Martin, Nicholas G.
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Martikainen, Pekka,1966-Stockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),University of Helsinki, Finland; The Max Planck Institute for Demographic Research, Germany(Swepub:su)pemar
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Medland, Sarah E.
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Morris, Tim T.
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Nivard, Michel G.
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Pingault, Jean-Baptiste
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Silventoinen, Karri
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Smith, Jennifer A.
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Willoughby, Emily A.
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Wilson, James F.
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Asvold, Bjorn Olav
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Naess, Oyvind E.
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Davey Smith, George
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Kaprio, Jaakko
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Brumpton, Ben
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Davies, Neil M.
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Stockholms universitetCentrum för forskning om ojämlikhet i hälsa (CHESS)
(creator_code:org_t)
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In:International Journal of Epidemiology52:5, s. 1579-15910300-57711464-3685
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Howe, Laurence J ...
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Rasheed, Humaira
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Jones, Paul R.
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Boomsma, Dorret
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Evans, David M.
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Giannelis, Alexa ...
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Hayward, Carolin ...
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Hopper, John L.
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Hughes, Amanda
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Lahtinen, Hannu
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Li, Shuai
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Lind, Penelope A ...
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Martin, Nicholas ...
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Martikainen, Pek ...
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Medland, Sarah E ...
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Morris, Tim T.
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Nivard, Michel G ...
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Pingault, Jean-B ...
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Silventoinen, Ka ...
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Smith, Jennifer ...
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Willoughby, Emil ...
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Wilson, James F.
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Asvold, Bjorn Ol ...
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Naess, Oyvind E.
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Davey Smith, Geo ...
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Kaprio, Jaakko
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Brumpton, Ben
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Davies, Neil M.
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