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Associations between the IL-4 -590 T allele and Plasmodium falciparum infection prevalence in asymptomatic Fulani of Mali
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- Vafa, Manijeh (author)
- Stockholms universitet,Wenner-Grens institut
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Maiga, Bakary (author)
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Berzins, Klavs (author)
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Hayano, Masashi (author)
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Bereczky, Sandor (author)
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Dolo, Amagana (author)
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Daou, Modibo (author)
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Arama, Charles (author)
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Kouriba, Bourema (author)
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- Färnert, Anna (author)
- Karolinska Institutet
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- Doumbo, Ogobara K. (author)
- Stockholms universitet,Wenner-Grens institut
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- Troye-Blomberg, Marita (author)
- Stockholms universitet,Wenner-Grens institut
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
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In: Microbes and infection. - : Elsevier BV. - 1286-4579 .- 1769-714X. ; 9:9, s. 1043-1048
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In this study, we compared the genotype and allele frequencies of the IL-10 -1087 A/G and IL-4 -590 C/T single nucleotide polymorphisms in asymptomatic subjects of two sympatric ethnic tribes differing in susceptibility to malaria, the Fulani and the Dogon in Mali. The genotype data was correlated with ethnicity and malariometric indexes. A statistically significant inter-ethnic difference in allele and genotype frequency for both loci was noted (P < 0.0001). Within the Fulani, the prevalence of Plasmodium falciparum infection, as detected by both microscopy and PCR, was associated with the IL-4 -590 T allele (P = 0.005 and P = 0.0005, respectively), whereas, no such associations were seen in the Dogon. Inter-ethnic differences in spleen rates, higher in the Fulani than the Dogon, were seen between T carriers (TT and CT) of both groups (P < 0.0001). Parasite densities and number of concurrent clones did not vary between IL-4 genotypes within any of the studied groups. These results suggest an association between the IL-4 -590 T allele and P. falciparum prevalence within the Fulani but not the Dogon. No associations between IL-10 genotypes and studied malariometric indexes were observed in any of the two communities.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vafa, Manijeh
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Maiga, Bakary
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Berzins, Klavs
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Hayano, Masashi
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Bereczky, Sandor
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Dolo, Amagana
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show more...
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Daou, Modibo
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Arama, Charles
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Kouriba, Bourema
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Färnert, Anna
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Doumbo, Ogobara ...
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Troye-Blomberg, ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Microbes and inf ...
- By the university
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Stockholm University
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Karolinska Institutet