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The structure of th...
The structure of the PP2A regulatory subunit B56gamma : The remaining piece of the PP2A jigsaw puzzle
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- Magnusdottir, Audur (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Stenmark, Pål (författare)
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Flodin, Susanne (författare)
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- Nyman, Tomas (författare)
- Karolinska Institutet
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Kotenyova, Tatyana (författare)
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- Gräslund, Susanne (författare)
- Karolinska Institutet
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Ogg, Derek (författare)
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- Nordlund, Pär (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Wiley, 2009
- 2009
- Engelska.
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Ingår i: Proteins. - : Wiley. - 0887-3585 .- 1097-0134. ; 74:1, s. 212-221
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The PP2A serine/threonine phosphatase regulates a plethora of cellular processes. In the cell the predominant form of the enzyme is a heterotrimer, formed by a core dimer composed of a catalytic and a scaffolding subunit, which assemble together with one of a range of different regulatory B subunits. Here, we present the first structure of a free non-complexed B subunit, B56. Comparison with the recent structures of a heterotrimeric complex and the core dimer reveals several significant conformational changes in the interface region between the B56 and the core dimer. These allow for an assembly scheme of the PP2A holoenzyme to be put forth where B56 first complexes with the scaffolding subunit and subsequently binds to the catalytic subunit and this induces the formation of a binding site for the invariant C-terminus of the catalytic subunit that locks in the complex as a last step of assembly.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- crystal structure
- holoenzyme assembly
- PP2A regulation
- PR61
- B56
- B regulatory subunits
- protein phosphatase
- Biochemistry
- Biokemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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