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  • Bolad, Ahmed (author)

Distinct interethnic differences in IgG class/subclass and IgM antibody responses to malaria antigens but not in IgG responses to non-malarial antigens in sympatric tribes living in West Africa

  • Article/chapterEnglish2005

Publisher, publication year, extent ...

  • Wiley,2005
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-25595
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-25595URI
  • https://doi.org/10.1111/j.1365-3083.2005.01587.xDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-23516URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The well-established relative resistance to malaria observed in the Fulani ascompared with other sympatric tribes in West Africa has been attributed totheir higher levels of serum immunoglobulin (Ig) G antibodies to malarialantigens. In this study, we confirm and extend the previous findings by analysesof the levels of IgM, IgG and IgG subclasses of anti-malarial antibodies inasymptomatic individuals of different sympatric tribes in Burkina Faso(Fulani/Mossi) and Mali (Fulani/Dogon). The Fulani showed significantlyhigher median concentrations of anti-malarial IgG and IgM antibodies thanthe sympatric tribes at both locations. Although the overall subclass pattern ofantibodies did not differ between the tribes, with IgG1 and IgG3 as dominant,the Fulani showed consistently significantly higher levels of these subclasses ascompared with those of the non-Fulani individuals. No significant differenceswere seen in the levels of total IgG between the tribes, but the Fulani showedsignificantly higher levels of total IgM than their neighbours in both countries.While the antibody levels to some nonmalarial antigens showed the same patternof differences seen for antibody levels to malaria antigens, no significant suchdifferences were seen with antibodies to other nonmalarial antigens. In conclusion,our results show that the Fulani in two different countries show higherlevels of anti-malarial antibodies than sympatric tribes, and this appears not tobe a reflection of a general hyper-reactivity in the Fulani.

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  • Farouk, Salah E.Stockholms universitet,Wenner-Grens institut (author)
  • Modiano, David (author)
  • Berzins, KlavsStockholms universitet,Wenner-Grens institut(Swepub:su)klavs (author)
  • Troye-Blomberg, MaritaStockholms universitet,Wenner-Grens institut(Swepub:su)marita (author)
  • Israelsson, ElisabethStockholms universitet,Wenner-Grens institut (author)
  • Dolo, Amagana (author)
  • Doumbo, Ogobara K. (author)
  • Nebié, Issa (author)
  • Maiga, Boubacar (author)
  • Kouriba, Bourema (author)
  • Luoni, Gaia (author)
  • Sirima, Bienveu Sodiomon (author)
  • Stockholms universitetWenner-Grens institut (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Immunology: Wiley61:4, s. 380-3860300-94751365-3083

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