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3-(4-hydroxymethylp...
3-(4-hydroxymethylphenylsulfanyl)propanoic acid (HMPPA) as a new safety catch linker in solid phase peptide synthesis
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- Erlandsson, Mikael (author)
- Stockholms universitet,Institutionen för neurokemi
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- Undén, Anders (author)
- Stockholms universitet,Institutionen för neurokemi
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(creator_code:org_t)
- Elsevier Ltd, 2006
- 2006
- English.
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In: Tetrahedron Letters. - : Elsevier Ltd. - 0040-4039 .- 1359-8562. ; 32:7, s. 5829-5832
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A new safety catch linker, 3-(4-hydroxymethylphenylsulfanyl)propanoic acid (HMPPA), is described for use in solid phase peptide synthesis. The linker is readily synthesized from commercially available chemicals in a more cost efficient way compared to similar reported linkers. The HMPPA linker is easily attached to an amino derivatized solid support followed by on-resin oxidation of the thioether to sulfoxide, thereby making the linker very stable towards strong acid treatment. Final resin cleavage is performed by reductive acidolysis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Neurochemistry
- Neurokemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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