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PARP is activated a...
PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-07-23
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Wiley,2009
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LIBRIS-ID:oai:DiVA.org:su-32006
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-32006URI
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https://doi.org/10.1038/emboj.2009.206DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show that poly(ADP-ribose) polymerase 1 (PARP1) binds to and is activated by stalled replication forks that contain small gaps. PARP1 collaborates with Mre11 to promote replication fork restart after release from replication blocks, most likely by recruiting Mre11 to the replication fork to promote resection of DNA. Both PARP1 and PARP2 are required for hydroxyurea-induced homologous recombination to promote cell survival after replication blocks. Together, our data suggest that PARP1 and PARP2 detect disrupted replication forks and attract Mre11 for end processing that is required for subsequent recombination repair and restart of replication forks.
Added entries (persons, corporate bodies, meetings, titles ...)
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Petermann, Eva
(author)
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Schultz, NiklasStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)nschu
(author)
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Jemth, Ann-SofieStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)annj
(author)
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Loseva, OlgaStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)losev
(author)
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Issaeva, Natalia
(author)
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Johansson, FredrikStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)fjoha
(author)
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Fernandez, Serena
(author)
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McGlynn, Peter
(author)
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Helleday, ThomasStockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi(Swepub:su)helleday
(author)
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Stockholms universitetInstitutionen för genetik, mikrobiologi och toxikologi
(creator_code:org_t)
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In:The EMBO journal: Wiley28:17, s. 2601-151460-20750261-4189
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Bryant, Helen E
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Petermann, Eva
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Schultz, Niklas
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Jemth, Ann-Sofie
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Loseva, Olga
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Issaeva, Natalia
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Johansson, Fredr ...
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Fernandez, Seren ...
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McGlynn, Peter
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Helleday, Thomas
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Stockholm University