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Allergic women have...
Allergic women have reduced sHLA-G plasma levels at delivery.
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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2009-04-01
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Wiley,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-32994
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-32994URI
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https://doi.org/10.1111/j.1600-0897.2009.00703.xDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118566431URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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PROBLEM: HLA-G antigen maintains a tolerogenic condition at the foeto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings, we analyzed if sHLA-G and interleukin-10 (IL-10) could be influenced by pregnancy and labour in allergic and non-allergic women. METHOD OF STUDY: sHLA-G isoforms and IL-10 levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays. RESULTS: A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform. CONCLUSION: The data showed increased sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is mainly responsible for the increased sHLA-G levels at delivery.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Stignani, Marina
(author)
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Amoudruz, PetraStockholms universitet,Avdelningen för immunologi
(author)
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Nilsson, CarolineKarolinska Institutet
(author)
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Melchiorri, Loredana
(author)
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Baricordi, Olavio
(author)
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Sverremark-Ekström, EvaStockholms universitet,Avdelningen för immunologi(Swepub:su)esver
(author)
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Stockholms universitetAvdelningen för immunologi
(creator_code:org_t)
Related titles
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In:American Journal of Reproductive Immunology and Microbiology: Wiley61:5, s. 368-768755-89201046-74081600-0897
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