Search: onr:"swepub:oai:DiVA.org:su-48907" >
The Histone Deacety...
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1 alpha
-
Zhong, Lei (author)
-
D'Urso, Agustina (author)
-
Toiber, Debra (author)
-
show more...
-
Sebastian, Carlos (author)
-
Henry, Ryan E. (author)
-
Vadysirisack, Douangsone D. (author)
-
Guimaraes, Alexander (author)
-
Marinelli, Brett (author)
-
- Wikström, Jakob D. (author)
- Stockholms universitet,Wenner-Grens institut
-
Nir, Tomer (author)
-
Clish, Clary B. (author)
-
Vaitheesvaran, Bhavapriya (author)
-
Iliopoulos, Othon (author)
-
Kurland, Irwin (author)
-
Dor, Yuval (author)
-
Weissleder, Ralph (author)
-
Shirihai, Orian S. (author)
-
Ellisen, Leif W. (author)
-
Espinosa, Joaquin M. (author)
-
Mostoslavsky, Raul (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
-
In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 140:2, s. 280-293
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the transcription factor Hif1 alpha, a critical regulator of nutrient stress responses. Consistent with this notion, SIRT6-deficient cells exhibit increased Hif1 alpha activity and show increased glucose uptake with upregulation of glycolysis and diminished mitochondrial respiration. Our studies uncover a role for the chromatin factor SIRT6 as a master regulator of glucose homeostasis and may provide the basis for novel therapeutic approaches against metabolic diseases, such as diabetes and obesity.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Cell
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Zhong, Lei
-
D'Urso, Agustina
-
Toiber, Debra
-
Sebastian, Carlo ...
-
Henry, Ryan E.
-
Vadysirisack, Do ...
-
show more...
-
Guimaraes, Alexa ...
-
Marinelli, Brett
-
Wikström, Jakob ...
-
Nir, Tomer
-
Clish, Clary B.
-
Vaitheesvaran, B ...
-
Iliopoulos, Otho ...
-
Kurland, Irwin
-
Dor, Yuval
-
Weissleder, Ralp ...
-
Shirihai, Orian ...
-
Ellisen, Leif W.
-
Espinosa, Joaqui ...
-
Mostoslavsky, Ra ...
-
show less...
- Articles in the publication
-
Cell
- By the university
-
Stockholm University