Search: onr:"swepub:oai:DiVA.org:su-48907" >
The Histone Deacety...
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1 alpha
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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Elsevier BV,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-48907
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-48907URI
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https://doi.org/10.1016/j.cell.2009.12.041DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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authorCount :20
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SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes. Specifically, SIRT6 appears to function as a corepressor of the transcription factor Hif1 alpha, a critical regulator of nutrient stress responses. Consistent with this notion, SIRT6-deficient cells exhibit increased Hif1 alpha activity and show increased glucose uptake with upregulation of glycolysis and diminished mitochondrial respiration. Our studies uncover a role for the chromatin factor SIRT6 as a master regulator of glucose homeostasis and may provide the basis for novel therapeutic approaches against metabolic diseases, such as diabetes and obesity.
Subject headings and genre
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NATURAL SCIENCES
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NATURVETENSKAP
Added entries (persons, corporate bodies, meetings, titles ...)
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D'Urso, Agustina
(author)
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Toiber, Debra
(author)
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Sebastian, Carlos
(author)
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Henry, Ryan E.
(author)
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Vadysirisack, Douangsone D.
(author)
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Guimaraes, Alexander
(author)
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Marinelli, Brett
(author)
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Wikström, Jakob D.Stockholms universitet,Wenner-Grens institut
(author)
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Nir, Tomer
(author)
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Clish, Clary B.
(author)
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Vaitheesvaran, Bhavapriya
(author)
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Iliopoulos, Othon
(author)
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Kurland, Irwin
(author)
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Dor, Yuval
(author)
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Weissleder, Ralph
(author)
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Shirihai, Orian S.
(author)
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Ellisen, Leif W.
(author)
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Espinosa, Joaquin M.
(author)
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Mostoslavsky, Raul
(author)
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Stockholms universitetWenner-Grens institut
(creator_code:org_t)
Related titles
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In:Cell: Elsevier BV140:2, s. 280-2930092-86741097-4172
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Zhong, Lei
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D'Urso, Agustina
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Toiber, Debra
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Henry, Ryan E.
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Vadysirisack, Do ...
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Guimaraes, Alexa ...
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Marinelli, Brett
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Wikström, Jakob ...
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Nir, Tomer
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Clish, Clary B.
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Vaitheesvaran, B ...
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Iliopoulos, Otho ...
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Kurland, Irwin
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Dor, Yuval
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Weissleder, Ralp ...
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Shirihai, Orian ...
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Ellisen, Leif W.
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Espinosa, Joaqui ...
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Stockholm University