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Synthesis of the Le...
Synthesis of the Lewis b pentasaccharide and a HSA-conjugate thereof
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- Fourniere, Viviane (author)
- Univ Bangor, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
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- Skantz, Linnea (author)
- Stockholms universitet,Institutionen för organisk kemi,Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden.
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- Sajtos, Ferenc (author)
- Stockholms universitet,Institutionen för organisk kemi,Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden.
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- Oscarson, Stefan (author)
- Univ Coll Dublin, Ctr Synth & Chem Biol, Dublin 4, Ireland.
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- Lahmann, Martina (author)
- Univ Bangor, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
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Univ Bangor, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales Institutionen för organisk kemi (creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Tetrahedron. - : Elsevier BV. - 0040-4020 .- 1464-5416. ; 66:39, s. 7850-7855
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Helicobacter pylori, a gastric pathogen, binds to various blood group antigens, including the Lewis types, present in the gastric tissue and a relation between the presentation of the ligands and the overall strength of binding has been assumed. Synthetic Lewis b tetra- and hexasaccharide conjugates are available but not the analogous pentasaccharide. An efficient synthesis of the amino spacer equipped Lewis b pentasaccharide, 3-aminopropyl alpha-L-fucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 3)-[alpha-L-fucopyranosyl-(1 -> 4)]-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1 -> 3)-beta-D-galactopyranoside, is presented to enable further investigation of the carbohydrate recognition process of H. pylori.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Glycosylation
- Regioselective 3
- 4-benzylidene opening
- Glycoconjugates
- Helicobacter pylori
- Carbohydrate synthesis
- Organic chemistry
- Organisk kemi
- organisk kemi
- Organic Chemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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