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NordicDB :
NordicDB : a Nordic pool and portal for genome-wide control data
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Leu, Monica (author)
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- Humphreys, Keith (author)
- Karolinska Institutet
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Surakka, Ida (author)
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Rehnberg, Emil (author)
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Muilu, Juha (author)
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Rosenstrom, Paivi (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Jaaskelainen, Juha (author)
- Karolinska Institutet
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Lifton, Richard P. (author)
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Kyvik, Kirsten Ohm (author)
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Kaprio, Jaakko (author)
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Palotie, Aarno (author)
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- Hall, Per (author)
- Karolinska Institutet
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- Gronberg, Henrik (author)
- Karolinska Institutet
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Peltonen, Leena (author)
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- Palmgren, Juni (author)
- Stockholms universitet,Matematiska institutionen
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Ripatti, Samuli (author)
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(creator_code:org_t)
- 2010-07-28
- 2010
- English.
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In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 18:12, s. 1322-1326
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http://dx.doi.org/10...
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Abstract
Subject headings
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- A cost-efficient way to increase power in a genetic association study is to pool controls from different sources. The genotyping effort can then be directed to large case series. The Nordic Control database, NordicDB, has been set up as a unique resource in the Nordic area and the data are available for authorized users through the web portal (http://www.nordicdb.org). The current version of NordicDB pools together high-density genome-wide SNP information from similar to 5000 controls originating from Finnish, Swedish and Danish studies and shows country-specific allele frequencies for SNP markers. The genetic homogeneity of the samples was investigated using multidimensional scaling (MDS) analysis and pairwise allele frequency differences between the studies. The plot of the first two MDS components showed excellent resemblance to the geographical placement of the samples, with a clear NW-SE gradient. We advise researchers to assess the impact of population structure when incorporating NordicDB controls in association studies. This harmonized Nordic database presents a unique genome-wide resource for future genetic association studies in the Nordic countries. European Journal of Human Genetics (2010) 18, 1322-1326; doi: 10.1038/ejhg.2010.112; published online 28 July 2010
Subject headings
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- common controls
- genome-wide data
- Nordic Control Database
- population stratification
- MATHEMATICS
- MATEMATIK
- population
- stratification
- Nordic Control Database
- common controls
- genome-wide data
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Leu, Monica
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Humphreys, Keith
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Surakka, Ida
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Rehnberg, Emil
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Muilu, Juha
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Rosenstrom, Paiv ...
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show more...
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Almgren, Peter
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Jaaskelainen, Ju ...
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Lifton, Richard ...
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Kyvik, Kirsten O ...
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Kaprio, Jaakko
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Pedersen, Nancy ...
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Palotie, Aarno
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Hall, Per
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Gronberg, Henrik
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Groop, Leif
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Peltonen, Leena
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Palmgren, Juni
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Ripatti, Samuli
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Mathematics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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European Journal ...
- By the university
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Stockholm University
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Lund University
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Karolinska Institutet