Search: onr:"swepub:oai:DiVA.org:su-54521" >
Electron capture in...
-
Haag, NicoleStockholms universitet,Fysikum
(author)
Electron capture induced dissociation of doubly protonated pentapeptides : Dependence on molecular structure and charge separation
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
AIP Publishing,2011
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-54521
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54521URI
-
https://doi.org/10.1063/1.3533952DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We have studied electron capture induced dissociation of a set of doubly protonated pentapeptides, all composed of one lysine (K) and either four glycine (G) or four alanine (A) residues, as a function of the sequence of these building blocks. Thereby the separation of the two charges, sequestered on the N-terminal amino group and the lysine side chain, is varied. The characteristic cleavage of N–Cα bonds is observed for all peptides over the whole backbone length, with the charge carrying fragments always containing K. The resulting fragmentation patterns are very similar if G is replaced by A. In the case of [XKXXX+2H]2+ (X=A or G), a distinct feature is observed in the distribution of backbone cleavage fragments and the probability for ammonia loss is drastically reduced. This may be due to an isomer with an amide oxygen as protonation site giving rise to the observed increase in breakage at a specific site in the molecule. For the other peptides, a correlation with the distance between amide oxygen and the charge at the lysine side chain has been found. This may be an indication that it is only the contribution from this site to the charge stabilization of the amide π* orbitals which determines relative fragment intensities. For comparison, complexes with two crown ether molecules have been studied as well. The crown ether provides a shielding of the charge and prevents the peptide from folding and internal hydrogen bonding, which leads to a more uniform fragmentation behavior.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Holm, Anne I. S.Stockholms universitet,Fysikum(Swepub:su)anhol
(author)
-
Johansson, Henrik A. B.Stockholms universitet,Fysikum(Swepub:su)henjo
(author)
-
Zettergren, HenningStockholms universitet,Fysikum(Swepub:su)henning
(author)
-
Schmidt, Henning T.Stockholms universitet,Fysikum(Swepub:su)schmidt
(author)
-
Brøndsted Nielsen, Steen
(author)
-
Hvelplund, Preben
(author)
-
Cederquist, HenrikStockholms universitet,Fysikum(Swepub:su)cederq
(author)
-
Stockholms universitetFysikum
(creator_code:org_t)
Related titles
-
In:Journal of Chemical Physics: AIP Publishing134:3, s. 035102-0021-96061089-7690
Internet link
Find in a library
To the university's database