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Adrenergic stimulat...
Adrenergic stimulation of glucose uptake in brown adipocytes
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- Chernogubova, Ekaterina, 1967- (author)
- Stockholms universitet,Wenner-Grens institut
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- Bengtsson, Tore (thesis advisor)
- Stockholms universitet,Wenner-Grens institut
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- Cannon, Barbara (thesis advisor)
- Stockholms universitet,Wenner-Grens institut
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- Cushman, Samuel (opponent)
- NIDDK, NIH
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(creator_code:org_t)
- ISBN 9171550968
- Stockholm : Wenner-Grens institut för experimentell biologi, 2005
- English 129 s.
- Related links:
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https://su.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The aim of this study was to investigate adrenergically stimulated glucose uptake in brown adipose tissue (BAT) with the focus on receptor subtypes and intracellular signalling pathways. As a model system, we used primary cultured brown adipocytes.Adrenergic stimulation of glucose uptake occurs via β3-AR in wild type cells and β1-/α1-ARs in β3-KO cells, includes activation of adenylyl cyclase and cAMP formation, activation of PKA, PI3K, PKC and AMPK (Paper I, II, III). Interestingly, UCP1 activity is not required for the AMPK function in brown adipocytes (Paper III). Long-term adrenergic stimulation of glucose uptake induces an increase in GLUT1 mRNA and protein levels stimulating GLUT1 translocation to the plasma membrane (Paper IV).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Physiology
- Fysiologi
Publication and Content Type
- vet (subject category)
- dok (subject category)
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