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Reduced neuronal ef...
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Vannini, PatriziaKarolinska Institutet
(author)
Reduced neuronal efficacy in progressive mild cognitive impairment : A prospective fMRI study on visuospatial processing
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Elsevier BV,2007
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Numbers
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LIBRIS-ID:oai:DiVA.org:su-55757
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55757URI
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https://doi.org/10.1016/j.pscychresns.2007.02.003DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:116092066URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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authorCount :5
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Mild cognitive impairment (MCI) often refers to the preclinical stage of dementia, where the majority develop Alzheimer's disease (AD). Given that neurodegenerative burden and compensatory mechanisms might exist before accepted clinical symptoms of AD are noticeable, the current prospective study aimed to investigate the functioning of brain regions in the visuospatial networks responsible for preclinical symptoms in AD using event-related functional magnetic resonance imaging (fMRI). Eighteen MCI patients were evaluated and clinically followed for approximately 3 years. Five progressed to AD (PMCI) and eight remained stable (SMCI). Thirteen age-, gender- and education-matched controls also participated. An angle discrimination task with varying task demands was used. Brain activation patterns as well as task demand-dependent and -independent signal changes between the groups were investigated by using an extended general linear model including individual performance (reaction time [RT]) of each single trial. Similar behavioral (RT and accuracy) responses were observed between MCI patients and controls. A network of bilateral activations, e.g. dorsal pathway, which increased linearly with increasing task demand, was engaged in all subjects. Compared with SMCI patients and controls, PMCI patients showed a stronger relation between task demand and brain activity in left superior parietal lobules (SPL) as well as a general task demand-independent increased activation in left precuneus. Altered brain function can be detected at a group level in individuals that progress to AD before changes occur at the behavioral level. Increased parictal activation in PMCI could reflect a reduced neuronal efficacy due to accumulating AD pathology and might predict future clinical decline in patients with MCI.
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Almkvist, OveKarolinska Institutet,Stockholms universitet,Psykologiska institutionen
(author)
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Dierks, Thomas
(author)
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Lehmann, Christoph
(author)
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Wahlund, Lars-OlofKarolinska Institutet
(author)
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Karolinska InstitutetPsykologiska institutionen
(creator_code:org_t)
Related titles
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In:Psychiatry Research: Elsevier BV156:1, s. 43-570925-49271872-75060165-1781
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