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Comparative analysi...
Comparative analysis of RNA families reveals distinct repertoires for each domain of life
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- Hoeppner, Marc Patrick, 1980- (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik,Poole
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- Gardner, Paul P. (author)
- Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus
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- Poole, Anthony M. (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik,Poole
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Some RNAs may date back to an RNA-rich period in the early evolution of life, butmany RNAs are thought to have more recent evolutionary origins. To chart the broadevolutionary history of known RNA families, we performed comparative genomicanalysis of over 3 million RNA annotations spanning 1446 families from the Rfam 10database. We report that 99% of known RNA families are restricted to a singledomain of life, revealing discrete repertoires for each domain. For the 1% of RNAfamilies/clans present in more than one domain, over half show evidence ofhorizontal gene transfer (HGT), and only six RNAs directly trace to the LastUniversal Common Ancestor (LUCA). These results indicate that cellular RNAinfrastructure evolves in a domain-specific manner.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- RNA
- comparative genomics
- tree of life
- Molecular biology
- Molekylärbiologi
- Molecular Biology
- molekylärbiologi
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database