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The VIZIER project :
The VIZIER project : Preparedness against pathogenic RNA viruses
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Coutard, B. (author)
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Gorbalenya, A. E. (author)
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Snijder, E. J. (author)
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Leontovich, A. M. (author)
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Poupon, A. (author)
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De lamballerie, X. (author)
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Charrel, R. (author)
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Gould, E. A. (author)
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Gunther, S. (author)
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Norder, H. (author)
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Klempa, B. (author)
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Bourhy, H. (author)
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Rohayem, J. (author)
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L'hermite, E. (author)
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- Nordlund, P. (author)
- Karolinska Institutet,Stockholms universitet,Institutionen för biokemi och biofysik
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Stuart, D. I. (author)
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Owens, R. J. (author)
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Grimes, J. M. (author)
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Tucker, P. A. (author)
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Bolognesi, M. (author)
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Mattevi, A. (author)
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Coll, M. (author)
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- Jones, T. A. (author)
- Uppsala universitet,Strukturell molekylärbiologi
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Aqvist, J. (author)
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- Unge, T. (author)
- Uppsala universitet,Strukturell molekylärbiologi
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Hilgenfeld, R. (author)
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Bricogne, G. (author)
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Neyts, J. (author)
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La Colla, P. (author)
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Puerstinger, G. (author)
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Gonzalez, J. P. (author)
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Leroy, E. (author)
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Cambillau, C. (author)
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Romette, J. L. (author)
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Canard, B. (author)
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- English.
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In: Antiviral Research. - : Elsevier BV. - 0166-3542 .- 1872-9096. ; 78:1, s. 37-46
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- Life-threatening RNA viruses emerge regularly, and often in an unpredictable manner. Yet, the very few drugs available against known RNA viruses have sometimes required decades of research for development. Can we generate preparedness for outbreaks of the, as yet, unknown viruses? The VIZIER (VIral enZymes InvolvEd in Replication) (http://www.vizier-europe.org/) project has been set-up to develop the scientific foundations for countering this challenge to society. VIZIER studies the most conserved viral enzymes (that of the replication machinery, or replicases) that constitute attractive targets for drug-design. The aim of VIZIER is to determine as many replicase crystal structures as possible from a carefully selected list of viruses in order to comprehensively cover the diversity of the RNA virus universe, and generate critical knowledge that could be efficiently utilized to jump-start research on any emerging RNA virus. VIZIER is a multidisciplinary project involving (i) bioinformatics to define functional domains, (ii) viral genomics to increase the number of characterized viral genomes and prepare defined targets, (iii) proteomics to express, purify, and characterize targets, (iv) structural biology to solve their crystal structures, and (v) pre-lead discovery to propose active scaffolds of antiviral molecules.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- RNA virus
- genomics
- crystal structure
- replicase
- antivirals
- drug-design
- Biochemistry
- Biokemi
- Cell and molecular biology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Coutard, B.
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Gorbalenya, A. E ...
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Snijder, E. J.
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Leontovich, A. M ...
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Poupon, A.
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De lamballerie, ...
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show more...
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Charrel, R.
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Gould, E. A.
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Gunther, S.
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Norder, H.
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Klempa, B.
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Bourhy, H.
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Rohayem, J.
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L'hermite, E.
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Nordlund, P.
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Stuart, D. I.
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Owens, R. J.
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Grimes, J. M.
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Tucker, P. A.
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Bolognesi, M.
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Mattevi, A.
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Coll, M.
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Jones, T. A.
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Aqvist, J.
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Unge, T.
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Hilgenfeld, R.
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Bricogne, G.
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Neyts, J.
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La Colla, P.
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Puerstinger, G.
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Gonzalez, J. P.
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Leroy, E.
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Cambillau, C.
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Romette, J. L.
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Canard, B.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Antiviral Resear ...
- By the university
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Stockholm University
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Uppsala University
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Karolinska Institutet