Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction

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Johansson, CatharinaKarolinska Institutet (author)

Elevated Peripheral Allergen-Specific T Cell Response Is Crucial for a Positive Atopy Patch Test Reaction

Article/chapterEnglish2009

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2009-04-02
S. Karger AG,2009
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LIBRIS-ID:oai:DiVA.org:su-60077
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-60077URI
https://doi.org/10.1159/000210380DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:118788912URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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authorCount :7
Background: Atopic eczema is a chronic inflammatory skin disease in which several subgroups of cases can be identified. Atopy patch testing (APT) reveals allergen sensitization also in atopic eczema patients devoid of detectable allergen-specific IgE, suggesting the importance of factors other than IgE in the reaction. Here we investigate the relationship between APT reactions and allergen-specific peripheral IgE and T cell reactivity in atopic eczema patients. Methods: Adult patients with atopic eczema (n = 64) and healthy controls (n = 24) were analyzed for reactivity to Malassezia sympodialis extract by APT, measurement of specific plasma IgE and in vitro determination of the frequency of allergen-reactive peripheral blood mononuclear cells producing interleukin-4 and interleukin-5 using the ELISpot method. Results: When combining the results of the APT, IgE measurements and the ELISpot analyses, reactivity to M. sympodialis was found in a majority of the atopic eczema patients (69%), whereas the healthy controls were negative throughout. T cell reactivity to M. sympodialis, manifested by production of both interleukins 4 and 5, was highly predictive for a positive APT reaction and displayed a strongly positive correlation with the APT score. In contrast, the allergen-specific IgE levels did not predict the APT outcome, and no correlation could be found between the IgE levels and the APT score. Conclusion: Peripheral allergen-specific T helper 2 cell-mediated reactivity appears to be required for a positive APT reaction to M. sympodialis. The diagnostic potential of measuring peripheral allergen-specific T cell responses should be considered in atopic eczema.

Subject headings and genre

NATURVETENSKAP Biologi Immunologi hsv//swe
NATURAL SCIENCES Biological Sciences Immunology hsv//eng
Antigen-specific IgE
Atopic eczema
Atopic dermatitis
Atopy patch test
ELISpot
Interleukin-4
Interleukin-5
Malassezia
Immunology
Immunologi

Added entries (persons, corporate bodies, meetings, titles ...)

Ahlborg, NiklasStockholms universitet,Avdelningen för immunologi (author)
Andersson, AnnaKarolinska Institutet (author)
Lundeberg, Lena (author)
Karlsson, Maria A. (author)
Scheynius, Annika (author)
Linder, Maria TengvallKarolinska Institutet (author)
Karolinska InstitutetAvdelningen för immunologi (creator_code:org_t)

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In:International Archives of Allergy and Immunology: S. Karger AG150:1, s. 51-581018-24381423-0097

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Immunology

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By the university: Stockholm University; Karolinska Institutet

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