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Glucose metabolism ...
Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation
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- Schöll, Michael (author)
- Karolinska Institutet
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- Almkvist, Ove (author)
- Karolinska Institutet,Stockholms universitet,Psykologiska institutionen
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Axelman, Karin (author)
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Stefanova, Elka (author)
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- Wall, Anders (author)
- Uppsala universitet,Enheten för nuklearmedicin och PET
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- Westman, Eric (author)
- Karolinska Institutet
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- Långström, Bengt (author)
- Uppsala universitet,Institutionen för biokemi och organisk kemi
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Graff, Caroline (author)
- Karolinska Institutet
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- Nordberg, Agneta (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 32:8, s. 1388-1399
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Six young related pre-symptomatic carriers of a His 163Tyr mutation in the presenilin 1 gene who will develop early onset familial Alzheimer's disease (eoFAD), and a control group of 23 non-carriers underwent (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). The mutation carriers were followed-up after 2 years. Multivariate analysis showed clear separation of carriers from non-carriers on both occasions, with the right thalamus being the region contributing most to group differentiation. Statistical parametric mapping (SPM) revealed in the carriers non-significantly lower thalamic cerebral glucos metabolism (CMRglc) at baseline and significantly decreased CMRglc in the right thalamus at follow-up. One mutation carrier was followed-up with FDG PET 10 years after baseline and showed reductions in cognition and CMRglc in the posterior cingulate and the frontal cortex. This subject was diagnosed with AD 1 year later and assessed with an additional FDG as well as an (11)C-PIB PET scan 12 years after baseline. Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Early onset familial Alzheimer's disease
- Presenilin 1
- (18)F-FDG PET
- (11)C-PIB PET
- Pre-symptomatic
- Longitudinal
- Psychology
- Psykologi
- Psychology
- psykologi
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Schöll, Michael
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Almkvist, Ove
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Axelman, Karin
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Stefanova, Elka
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Wall, Anders
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Westman, Eric
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show more...
-
Långström, Bengt
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Lannfelt, Lars
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Graff, Caroline
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Nordberg, Agneta
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurobiology of ...
- By the university
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Stockholm University
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Uppsala University
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Karolinska Institutet