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Regional Difference...
Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects
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- Norberg, Joakim (author)
- Stockholms universitet,Psykologiska institutionen
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Graff, C. (author)
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- Almkvist, Ove (author)
- Stockholms universitet,Psykologiska institutionen
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Ewers, M. (author)
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Frisoni, G. B. (author)
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Froelich, L. (author)
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Hampel, H. (author)
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Jones, R. W. (author)
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Kehoe, P. G. (author)
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Lenoir, H. (author)
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- Minthon, Lennart (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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Nobili, F. (author)
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Rikkert, M. Olde (author)
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Rigaud, A. -S (author)
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Scheltens, P. (author)
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Soininen, H. (author)
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Spiru, L. (author)
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Tsolaki, M. (author)
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Wahlund, L. -O (author)
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Vellas, B. (author)
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Wilcock, G. (author)
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Elias-Sonnenschein, L. S. (author)
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Verhey, F. R. J. (author)
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Visser, P. J. (author)
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(creator_code:org_t)
- 2011-09-22
- 2011
- English.
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In: Dementia and Geriatric Cognitive Disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 32:2, s. 135-142
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- APOE epsilon 4 allele
- Europe
- Gradient
- Psychology
- Psykologi
- Psychology
- psykologi
- Alzheimer's disease
- APOE epsilon 4 allele
- Europe
- Gradient
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Norberg, Joakim
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Graff, C.
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Almkvist, Ove
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Ewers, M.
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Frisoni, G. B.
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Froelich, L.
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show more...
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Hampel, H.
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Jones, R. W.
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Kehoe, P. G.
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Lenoir, H.
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Minthon, Lennart
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Nobili, F.
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Rikkert, M. Olde
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Rigaud, A. -S
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Scheltens, P.
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Soininen, H.
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Spiru, L.
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Tsolaki, M.
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Wahlund, L. -O
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Vellas, B.
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Wilcock, G.
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Elias-Sonnensche ...
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Verhey, F. R. J.
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Visser, P. J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Dementia and Ger ...
- By the university
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Stockholm University
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Lund University