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The manganese ion of the heterodinuclear Mn/Fe cofactor in Chlamydia trachomatis ribonucleotide reductase R2c is located at metal position 1.

Andersson, Charlotta S., 1979- (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Öhrström, Maria (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Popović-Bijelić, Ana (author)
Stockholms universitet,Institutionen för biokemi och biofysik
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Gräslund, Astrid (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Stenmark, Pål (author)
Stockholms universitet,Institutionen för biokemi och biofysik
Högbom, Martin (author)
Stockholms universitet,Institutionen för biokemi och biofysik
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 (creator_code:org_t)
2011-12-08
2012
English.
In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 134:1, s. 123-125
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The essential catalytic radical of Class-I ribonucleotide reductase is generated and delivered by protein R2, carrying a dinuclear metal cofactor. A new R2 subclass, R2c, prototyped by the Chlamydia trachomatis protein was recently discovered. This protein carries an oxygen-activating heterodinuclear Mn(II)/Fe(II) metal cofactor and generates a radical-equivalent Mn(IV)/Fe(III) oxidation state of the metal site, as opposed to the tyrosyl radical generated by other R2 subclasses. The metal arrangement of the heterodinuclear cofactor remains unknown. Is the metal positioning specific, and if so, where is which ion located? Here we use X-ray crystallography with anomalous scattering to show that the metal arrangement of this cofactor is specific with the manganese ion occupying metal position 1. This is the position proximal to the tyrosyl radical site in other R2 proteins and consistent with the assumption that the high-valent Mn(IV) species functions as a direct substitute for the tyrosyl radical.

Subject headings

NATURVETENSKAP  -- Biologi -- Strukturbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Structural Biology (hsv//eng)

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ref (subject category)
art (subject category)

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