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Type I interferons ...
Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells : Differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Elsevier BV,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-77001
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-77001URI
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https://doi.org/10.1016/j.cyto.2011.12.001DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124155473URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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12
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Type I interferons (IFN) exert multiple effects on both the innate and adaptive immune system in addition to their antiviral and antiproliferative activities. Little is known, however about the direct effects of type IFNs on germinal center (GC) B cells, the central components of adaptive B cell responses. We used Burkitt's lymphoma (BL) lines, as a model system of normal human GC B cells, to examine the effect of type I IFNs on the expression of BCL-6, the major regulator of the GC reaction. We show that type I IFNs, but not IFN gamma, IL-2 and TNF alpha rapidly down-regulate BCL-6 protein and mRNA expression, in cell lines derived from endemic, but not from sporadic BL. IFN alpha-induced down-regulation is specific for BCL-6, independent of Epstein-Barr virus and is not accompanied by IRF-4 up-regulation. IFN alpha-induced BCL-6 mRNA down-regulation does not require de novo protein synthesis and is specifically inhibited by piceatannol. The proteasome inhibitor mG132 non-specifically prevents, while inhibitors of alternate type I IFN signaling pathways do not inhibit IFNa-induced BCL-6 protein downregulation. We validate our results with showing that IFN alpha rapidly down-regulates BCL-6 mRNA in purified mouse normal GC B cells. Our results identify type I IFNs as the first group of cytokines that can down-regulate BCL-6 expression directly in GC B cells.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Adori, MonikaKarolinska Institutet
(author)
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He, Minghui,1983-Stockholms universitet,Wenner-Grens institut(Swepub:su)mihe7483
(author)
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Bonelt, PeterStockholms universitet,Wenner-Grens institut
(author)
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Severinson, EvaStockholms universitet,Wenner-Grens institut(Swepub:su)sever
(author)
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Kis, Lorand L.Karolinska Institutet
(author)
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Wu, Liang
(author)
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Ujvari, DorinaKarolinska Institutet
(author)
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Leveau, Benjamin
(author)
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Nagy, NoemiKarolinska Institutet
(author)
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Klein, GeorgeKarolinska Institutet
(author)
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Klein, EvaKarolinska Institutet
(author)
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Karolinska InstitutetWenner-Grens institut
(creator_code:org_t)
Related titles
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In:Cytokine: Elsevier BV57:3, s. 360-3711043-46661096-0023
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Cytokine
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Salmon, Daniel
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Adori, Monika
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He, Minghui, 198 ...
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Bonelt, Peter
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Severinson, Eva
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Kis, Lorand L.
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Wu, Liang
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Ujvari, Dorina
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Leveau, Benjamin
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Nagy, Noemi
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Klein, George
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Klein, Eva
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
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Cytokine
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Stockholm University
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Karolinska Institutet