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Heterologous prime-...
Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guerin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice
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- Arama, Charles (author)
- Stockholms universitet,Avdelningen för immunologi
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- Assefaw-Redda, Yohannes (author)
- Stockholms universitet,Avdelningen för immunologi
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Rodriguez, Ariane (author)
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- Fernández, Carmen (author)
- Stockholms universitet,Avdelningen för immunologi
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Corradin, Giampietro (author)
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Kaufmann, Stefan H. E. (author)
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Reece, Stephen T. (author)
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- Troye-Blomberg, Marita (author)
- Stockholms universitet,Avdelningen för immunologi
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: Vaccine. - : Elsevier BV. - 0264-410X .- 1873-2518. ; 30:27, s. 4040-4045
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: Sustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines. Heterologous prime-boost approaches with vectors are optimal strategies to improve a broad and prolonged immunogenicity of malaria vaccines. Results: In this study, we demonstrate that the heterologous prime-boost regimen Ad35-CS/BCG-CS induces stronger immune responses by enhancing type 1 cellular producing-cells with high levels of CSp-specific IFN-gamma and cytophilic IgG2a antibodies as compared to a homologous BCG-CS and a heterologous BCG-CS/CSp prime-boost regimen. Moreover, the heterologous prime-boost regimen elicits the highest level of LLPC-mediated immune responses. Conclusion: The increased IFN-gamma-producing cell responses induced by the combination of Ad35-CS/BCG-CS and sustained type 1 antibody profile together with high levels of LLPCs may be essential for the development of long-term protective immunity against liver-stage parasites.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Malaria vaccines
- Plasmodium falciparum circumsporozoite protein
- Heterologous prime-boost
- Ad35-CS
- BCC-CS
- Long-lived plasma cells
Publication and Content Type
- ref (subject category)
- art (subject category)
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