Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease

Almkvist, Ove (author): Karolinska Institutet,Stockholms universitet,Psykologiska institutionen

Wall, Anders (author): Uppsala universitet,Enheten för nuklearmedicin och PET

Engler, Henry (author): Uppsala universitet,Enheten för nuklearmedicin och PET,Uppsala University Hospital

Långström, Bengt (author): Uppsala universitet,Institutionen för biokemi och organisk kemi,Uppsala Universitet

(creator_code:org_t)

Elsevier, 2012
2012
English.
In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 33:1, s. 198.e1-198.e14

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Abstract Subject headings

In this study 5 patients with mild cognitive impairment (MCI) and 9 Alzheimer’s disease (AD) patients underwent respectively 3- and 5-year follow-up positron emission tomography (PET) studies with N-methyl [11C] 2-(4-methylaminophenyl)-6-hydroxy-benzothiazole (11C-PIB) and 18F-fluorodeoxyglucose (18F-FDG) to understand the time courses in AD disease processes. Significant increase in PIB retention as well as decrease in regional cerebral metabolic rate of glucose (rCMRglc) was observed at group level in the MCI patients while no significant change was observed in cognitive function. At group level the AD patients showed unchanged high PIB retention at 5-year follow-up compared with baseline. At the individual level, increased, stable, and decreased PIB retention were observed while disease progression was reflected in significant decrease in rCMRglc and cognition. In conclusion, after a long-term follow-up with PET, we observed an increase in fibrillar amyloid load in MCI patients followed by more stable level in clinical AD patients. The rCMRglc starts to decline in MCI patients and became more pronounced in clinical stage which related to continuous decline in cognition.

SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

By the author/editor: Kadir, Ahmadul; Almkvist, Ove; Forsberg, Anton; Wall, Anders; Engler, Henry; Långström, Bengt; show more...; Nordberg, Agneta; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

By the university: Stockholm University; Uppsala University; Karolinska Institutet

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