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Cyanobacteria Produ...
Cyanobacteria Produce N-(2-Aminoethyl)Glycine, a Backbone for Peptide Nucleic Acids Which May Have Been the First Genetic Molecules for Life on Earth
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Banack, Sandra Anne (author)
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Metcalf, James S. (author)
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- Jiang, Liying (author)
- Stockholms universitet,Institutionen för analytisk kemi
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Craighead, Derek (author)
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- Ilag, Leopold L. (author)
- Stockholms universitet,Institutionen för analytisk kemi
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Cox, Paul Alan (author)
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(creator_code:org_t)
- 2012-11-07
- 2012
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:11, s. e49043-
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Abstract
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- Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by the earliest forms of life on earth. We discovered that cyanobacteria produce N-(2-aminoethyl)glycine (AEG), a backbone for peptide nucleic acids. We detected AEG in axenic strains of cyanobacteria with an average concentration of 1 µg/g. We also detected AEG in environmental samples of cyanobacteria as both a free or weakly bound molecule and a tightly bound form released by acid hydrolysis, at concentrations ranging from not detected to 34 µg/g. The production of AEG by diverse taxa of cyanobacteria suggests that AEG may be a primitive feature which arose early in the evolution of life on earth
Subject headings
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Keyword
- Analytical Chemistry
- analytisk kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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