Search: onr:"swepub:oai:DiVA.org:su-85183" > High plasma levels ...
Fältnamn | Indikatorer | Metadata |
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000 | 04469naa a2200457 4500 | |
001 | oai:DiVA.org:su-85183 | |
003 | SwePub | |
008 | 130107s2010 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:120964092 | |
009 | oai:prod.swepub.kib.ki.se:136955000 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-851832 URI |
024 | 7 | a https://doi.org/10.3233/JAD-2010-0914502 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1209640922 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1369550002 URI |
040 | a (SwePub)sud (SwePub)kid (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mangialasche, Francescau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
245 | 1 0 | a High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age |
264 | 1 | a Amsterdam, Washington :b IOS Press,c 2010 |
338 | a print2 rdacarrier | |
520 | a In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng |
700 | 1 | a Kivipelto, Miiau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
700 | 1 | a Mecocci, Patrizia4 aut |
700 | 1 | a Rizzuto, Deborau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
700 | 1 | a Palmer, Katie4 aut |
700 | 1 | a Winblad, Bengtu Karolinska Institutet4 aut |
700 | 1 | a Fratiglioni, Laurau Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 aut |
700 | 1 | a Di Felice, F4 aut |
700 | 1 | a Pelini, L4 aut |
710 | 2 | a Stockholms universitetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
773 | 0 | t Journal of Alzheimer's disease : JADd Amsterdam, Washington : IOS Pressg 58:3, s. 131-140q 20:4<1029-1037x 1875-8908 |
773 | 0 | t GIORNALE DI GERONTOLOGIAd Amsterdam, Washington : IOS Pressg 58:3, s. 131-140q 58:3<131-140x 0017-0305 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-85183 |
856 | 4 8 | u https://doi.org/10.3233/JAD-2010-091450 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120964092 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136955000 |
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