Search: onr:"swepub:oai:DiVA.org:su-92631" >
History of Medicall...
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Tolppanen, Anna-Maija
(author)
History of Medically Treated Diabetes and Risk of Alzheimer Disease in a Nationwide Case-Control Study
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-06-12
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American Diabetes Association,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-92631
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-92631URI
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https://doi.org/10.2337/dc12-1287DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126917754URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AuthorCount:7;
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OBJECTIVE-Type 2 diabetes in midlife or late life increases the risk of Alzheimer disease (AD), and type 1 diabetes has been associated with a higher risk of detrimental cognitive outcomes, although studies from older adults are lacking. We investigated whether individuals with AD were more likely to have a history of diabetes than matched controls from the general aged population. RESEARCH DESIGN AND METHODS-Information on reimbursed diabetes medication (including both type 1 and 2 diabetes) of all Finnish individuals with reimbursed AD medication in 2005 (n = 28,093) and their AD-free control subjects during 1972-2005 was obtained from a special reimbursement register maintained by the Social Insurance Institute of Finland. RESULTS-The prevalence of diabetes was 11.4% in the whole study population, 10.7% (n = 3,012) among control subjects, and 12.0% (n = 3,372) among AD case subjects. People with AD were more likely to have diabetes than matched control subjects (unadjusted OR 1.14 [95% CI 1.08-1.20]), even after adjusting for cardiovascular diseases (OR 1.31 [1.22-1.41]). The associations were stronger with diabetes diagnosed at midlife (adjusted OR 1.60 [1.34-1.84] and 1.25 [1.16-1.36] for midlife and late-life diabetes, respectively). CONCLUSIONS-Individuals with clinically verified AD are more likely to have a history of clinically verified and medically treated diabetes than the general aged population, although the difference is small.
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Lavikainen, Piia
(author)
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Solomon, AlinaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of East Finland
(author)
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Kivipelto, MiiaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),University of East Finland
(author)
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Uusitupa, Matti
(author)
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Soininen, Hilkka
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Hartikainen, Sirpa
(author)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
Related titles
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In:Diabetes Care: American Diabetes Association36:7, s. 2015-20190149-59921935-5548
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