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NK cell responses t...
NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
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- Beziat, Vivien (author)
- Karolinska Institutet
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- Liu, Lisa L. (author)
- Karolinska Institutet
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Malmberg, Jenny-Ann (author)
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- Ivarsson, Martin A. (author)
- Karolinska Institutet
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- Sohlberg, Ebba (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Björklund, Andreas T. (author)
- Karolinska Institutet
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Retiere, Christelle (author)
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- Sverremark-Ekström, Eva (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Traherne, James (author)
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- Ljungman, Per (author)
- Karolinska Institutet
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- Schaffer, Marie (author)
- Karolinska Institutet
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Price, David A. (author)
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Trowsdale, John (author)
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- Michaelsson, Jakob (author)
- Karolinska Institutet
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- Ljunggren, Hans-Gustaf (author)
- Karolinska Institutet
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- Malmberg, Karl-Johan (author)
- Karolinska Institutet
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(creator_code:org_t)
- American Society of Hematology, 2013
- 2013
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 121:14, s. 2678-2688
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a given NK cell is genetically hard-wired, we hypothesized that KIR repertoire perturbations reflect expansions of unique NK-cell subsets and may be used to trace adaptation of the NK-cell compartment to virus infections. By determining the human KIR-ome at a single-cell level in more than 200 donors, we were able to analyze the magnitude of NK cell adaptation to virus infections in healthy individuals. Strikingly, infection with human cytomegalovirus (CMV), but not with other common herpesviruses, induced expansion and differentiation of KIR-expressing NK cells, visible as stable imprints in the repertoire. Education by inhibitory KIRs promoted the clonal-like expansion of NK cells, causing a bias for self-specific inhibitory KIRs. Furthermore, our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2, or KIR3DS1), in addition to NKG2C, in the expansion of human NK cells. These results provide new insight into the diversity of KIR repertoire and its adaptation to virus infection, suggesting a role for both activating and inhibitory KIRs in immunity to CMV infection.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Beziat, Vivien
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Liu, Lisa L.
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Malmberg, Jenny- ...
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Ivarsson, Martin ...
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Sohlberg, Ebba
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Björklund, Andre ...
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show more...
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Retiere, Christe ...
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Sverremark-Ekstr ...
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Traherne, James
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Ljungman, Per
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Schaffer, Marie
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Price, David A.
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Trowsdale, John
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Michaelsson, Jak ...
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Ljunggren, Hans- ...
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Malmberg, Karl-J ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Stockholm University
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Karolinska Institutet