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  • Sohlberg, Ebba,1982-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut (author)

CMV Seropositive Children Show Inhibition of In Vitro EBV Infection that is Associated with CD8+CD57+ T-cell Enrichment and IFN-g

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  • LIBRIS-ID:oai:DiVA.org:su-93008
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93008URI

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  • Language:English
  • Summary in:English

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  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

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  • Epstein-Barr virus (EBV), a human herpesvirus, is commonly acquired during childhood and persists latently in B cells. EBV seropositivity has been connected to immune modulatory effects such as altered T- and NK-cell functional responses as well as protection against early IgE-sensitization, but due to the asymptomatic presentation during childhood little is known regarding the infection process in children of different ages. Here, we used mononuclear cells from cord blood, 2-year and 5-year old EBV-naïve children for in vitro EBV infection. We show that the degree of EBV-induced B-cell activation and expansion differs between age groups and in particular in relation to IFN-g production capacity. EBV infection induced redistribution between B-cell subsets with enrichment of IgD+CD27+ cells (commonly referred to as non-switched memory) in infected cord blood cell cultures, and of IgD-CD27+ cells (switched memory) in cell cultures of older children. We also related results to serostatus to cytomegalovirus (CMV), a persistent herpesvirus that can affect differentiation status of T- and NK cells. As compared to CMV- children, the EBV-induced enrichment of IgD-CD27+ B cells was significantly reduced in infected cell cultures from CMV+ children. This effect was associated with high levels of IFN-g  and frequencies of highly mature CD8+CD57+ T cells in CMV+ children. Our results demonstrate that both a child’s age and serostatus to CMV will have an impact on EBV-induced B-cell activation and expansion, and points to the ability of viruses with immune-modulatory functions, like CMV, to impact on immune responses within the host system.

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  • Saghafian-Hedengren, ShanieStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut (author)
  • Rasul, Eashan (author)
  • Marchini, Giovanna (author)
  • Nilsson, Caroline (author)
  • Klein, Eva (author)
  • Nagy, Noémi (author)
  • Sverremark-Ekström, EvaStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)esver (author)
  • Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

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