Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways: Experimental and Epidemiological Studies in Humans

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Aho, Vilma (author)

Partial Sleep Restriction Activates Immune Response-Related Gene Expression Pathways : Experimental and Epidemiological Studies in Humans

Article/chapterEnglish2013

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2013-10-23
Public Library of Science (PLoS),2013
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LIBRIS-ID:oai:DiVA.org:su-96885
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-96885URI
https://doi.org/10.1371/journal.pone.0077184DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127646766URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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AuthorCount:16;
Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experimentally induced, partial sleep restriction and to verify their connection to insufficient sleep at population level. The experimental design simulated sleep restriction during a working week: sleep of healthy men (N = 9) was restricted to 4 h/night for five nights. The control subjects (N = 4) spent 8 h/night in bed. Leukocyte RNA expression was analyzed at baseline, after sleep restriction, and after recovery using whole genome microarrays complemented with pathway and transcription factor analysis. Expression levels of the ten most up-regulated and ten most down-regulated transcripts were correlated with subjective assessment of insufficient sleep in a population cohort (N = 472). Experimental sleep restriction altered the expression of 117 genes. Eight of the 25 most up-regulated transcripts were related to immune function. Accordingly, fifteen of the 25 most up-regulated Gene Ontology pathways were also related to immune function, including those for B cell activation, interleukin 8 production, and NF-kappa B signaling (P<0.005). Of the ten most up-regulated genes, expression of STX16 correlated negatively with self-reported insufficient sleep in a population sample, while three other genes showed tendency for positive correlation. Of the ten most down-regulated genes, TBX21 and LGR6 correlated negatively and TGFBR3 positively with insufficient sleep. Partial sleep restriction affects the regulation of signaling pathways related to the immune system. Some of these changes appear to be long-lasting and may at least partly explain how prolonged sleep restriction can contribute to inflammation-associated pathological states, such as cardiometabolic diseases.

Subject headings and genre

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng

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Ollila, Hanna M. (author)
Rantanen, Ville (author)
Kronholm, Erkki (author)
Surakka, Ida (author)
van Leeuwen, Wessel M. A.Stockholms universitet,Stressforskningsinstitutet,University of Helsinki, Finland; Finnish Institute of Occupational Health, Finland(Swepub:su)wvanl (author)
Lehto, Maili (author)
Matikainen, Sampsa (author)
Ripatti, Samuli (author)
Härmä, Mikko (author)
Sallinen, Mikael (author)
Salomaa, Veikko (author)
Jauhiainen, Matti (author)
Alenius, Harri (author)
Paunio, Tiina (author)
Porkka-Heiskanen, Tarja (author)
Stockholms universitetStressforskningsinstitutet (creator_code:org_t)

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In:PLOS ONE: Public Library of Science (PLoS)8:101932-6203

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By the author/editor: Aho, Vilma; Ollila, Hanna M.; Rantanen, Ville; Kronholm, Erkki; Surakka, Ida; van Leeuwen, Wes ...; show more...; Lehto, Maili; Matikainen, Samp ...; Ripatti, Samuli; Härmä, Mikko; Sallinen, Mikael; Salomaa, Veikko; Jauhiainen, Matt ...; Alenius, Harri; Paunio, Tiina; Porkka-Heiskanen ...; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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By the university: Stockholm University; Karolinska Institutet

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