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Midlife and Late-Li...
Midlife and Late-Life Body Mass Index and Late-Life Dementia : Results from a Prospective Population-Based Cohort
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- Tolppanen, Anna-Maija (författare)
- University of Eastern Finland
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- Ngandu, Tiia (författare)
- Karolinska Institutet
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- Kåreholt, Ingemar (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Jönköping University, Sweden,HHJ. Åldrande - livsvillkor och hälsa,HHJ, Institutet för gerontologi
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- Laatikainen, Tiina (författare)
- University of Eastern Finland
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- Rusanen, Minna (författare)
- University of Eastern Finland
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- Soininen, Hilkka (författare)
- University of Eastern Finland
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- Kivipelto, Miia (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Sweden; University of Eastern Finland, Finland
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(creator_code:org_t)
- 2014
- 2014
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 38:1, s. 201-209
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. Objective: The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/ Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities. Methods: The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria. Results: Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) andAD(1.20, 1.09-1.33). High late-lifeBMIwas associated with lower risk ofAD(0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03). Conclusion: Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- body mass index
- dementia
- obesity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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