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Low doses of γ-radi...
Low doses of γ-radiation induce consistent protein expression changes in human leukocytes
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- Skiöld, Sara (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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- Becker, Susanne (author)
- Karolinska University Hospital
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- Hellman, Ulf (author)
- Uppsala University
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- Auer, Gert (author)
- Karolinska University Hospital
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- Näslund, Ingemar (author)
- Karolinska University Hospital
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- Harms-Ringdahl, Mats (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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- Haghdoost, Siamak (author)
- Stockholms universitet,Institutionen för molekylärbiologi och funktionsgenomik
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(creator_code:org_t)
- Inderscience Publishers, 2011
- 2011
- English.
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In: International Journal of Low Radiation. - Inderscience Publishers. - 1477-6545 .- 1741-9190. ; 8:5/6, s. 374-387
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Twenty percent of cancer patients experience adverse effects after radiotherapy. The therapeutic doses are adjusted to the most sensitive individuals, resulting in a suboptimal dose for many patients. At present there is no screening system available to predict individual radiosensitivity. The main aim of this study is to investigate differences in protein expression pathways induced by low doses of radiation in whole blood obtained from radiosensitive and non–radiosensitive patients. To address this aim, a protocol for exposure condition, dose and analysis of whole blood was developed. The conditions for handling blood samples were optimised. The optimal doses and post irradiation conditions were determined. We found that 1 mGy and 150 mGy significantly changed protein expression in leukocytes collected from the two donors. The result shows that the protocol developed is suitable for characterisation of proteomic profiles associated with low dose exposure of leukocytes.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
Keyword
- low dose radiation; Oxidative stress; proteomics; whole blood; gamma radiation
- Molecular Biology
- molekylärbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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