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Mycobacterium tuber...
Mycobacterium tuberculosis PstS1 amplifies IFN-gamma and induces IL-17/IL-22 responses by unrelated memory CD4(+) T cells via dendritic cell activation
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Palma, Carla (författare)
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Schiavoni, Giovanna (författare)
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Abalsamo, Laura (författare)
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Mattei, Fabrizio (författare)
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Piccaro, Giovanni (författare)
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Sanchez, Massimo (författare)
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- Fernandez, Carmen (författare)
- Stockholms universitet,Avdelningen för immunologi
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Singh, Mahavir (författare)
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Gabriele, Lucia (författare)
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(creator_code:org_t)
- 2013-07-15
- 2013
- Engelska.
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 43:9, s. 2386-2397
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The immunological mechanisms that modulate protection during Mycobacterium tuberculosis (Mtb) infection or vaccination are not fully understood. Secretion of IFN- and, to a lesser extent, of IL-17 by CD4(+) T cells plays a major role both in protection and immunopathology. Few MtbAgs interacting with DCs affect priming, activation, and regulation of Ag-unrelated CD4(+) T-cell responses. Here we demonstrate that PstS1, a 38 kDa-lipoprotein of Mtb, promotes Ag-independent activation of memory T lymphocytes specific for Ag85B or Ag85A, two immunodominant protective Ags of Mtb. PstS1 expands CD4(+) and CD8(+) memory T cells, amplifies secretion of IFN- and IL-22 and induces IL-17 production by effector memory cells in an Ag-unrelated manner in vitro and in vivo. These effects were mediated through the stimulation of DCs, particularly of the CD8(-) subtype, which respond to PstS1 by undergoing phenotypic maturation and by secreting IL-6, IL-1 and, to a lower extent, IL-23. IL-6 secretion by PstS1-stimulated DCs was required for IFN-, and to a lesser extent for IL-22 responses by Ag85B-specific memory T cells. These results may open new perspectives for immunotherapeutic strategies to control Th1/Th17 immune responses in Mtb infections and in vaccinations against tuberculosis.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- DC
- Memory T cells
- Mycobacterium tuberculosis Ags
- Th1 response
- Th17 response
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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