Association between diabetes or antidiabetic therapy and lung cancer: A meta-analysis

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Wang, Zhida (author)

Association between diabetes or antidiabetic therapy and lung cancer : A meta-analysis

Article/chapterEnglish2013

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2013-07-15
Wiley-Blackwell,2013
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LIBRIS-ID:oai:DiVA.org:su-99142
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-99142URI
https://doi.org/10.1111/jdi.12112DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:127914790URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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AuthorCount:7;
Aims/IntroductionDiabetes can increase the risk of cancers at several sites, but the association between diabetes and lung cancer remains unclear. We aimed to provide the quantitative estimates for the association between diabetes or antidiabetic treatment and lung cancer risk in the present meta-analysis. Materials and MethodsCohort studies were identified by searching the PubMed database (January 1960 through October 2012) and manually assessing the cited references in the retrieved articles. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a random-effects model. Study quality was assessed using the Newcastle-Ottawa scale. ResultsA total of 19 cohort studies were included in the present meta-analysis. Of these, 14 studies focused on the association between diabetes and lung cancer incidence, and seven studies focused on the association between antidiabetic treatment and lung cancer incidence. Compared with non-diabetic individuals, diabetic patients do not have an increased risk of lung cancer (RR=1.04, 95% CI 0.87-1.24). The association between diabetes and lung cancer remained not statistically significant in subgroup analysis stratified by study characteristics, study quality, diabetes ascertainment or important confounders. A null association between insulin or biguanides therapy and lung cancer risk was found. However, the diabetic patients receiving thiazolidinedione (TZD) treatment had a 20% reduced risk of lung cancer than those without TZD treatment. ConclusionsNo association between diabetes and lung cancer risk was found. However, TZD treatment might reduce lung cancer risk in diabetic patients.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
Diabetes
Lung cancer
Meta-analysis

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Bao, Cuiping (author)
Su, Cheng (author)
Xu, WeiliStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
Luo, Hongbin (author)
Chen, Liming (author)
Qi, Xiuying (author)
Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

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In:Journal of Diabetes Investigation: Wiley-Blackwell4:6, s. 659-6662040-11162040-1124

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By the author/editor: Wang, Zhida; Bao, Cuiping; Su, Cheng; Xu, Weili; Luo, Hongbin; Chen, Liming; show more...; Qi, Xiuying; show less...

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