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The cerebrospinal f...
The cerebrospinal fluid cytokine signature of multiple sclerosis : A homogenous response that does not conform to the Th1/Th2/Th17 convention
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- Burman, Joachim (author)
- Uppsala universitet,Neurologi,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
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- Svensson, Emma (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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- Fransson, Moa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
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- Loskog, Angelica S I (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Raininko, Raili (author)
- Uppsala universitet,Enheten för radiologi
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- Svenningsson, Anders (author)
- Umeå universitet,Klinisk neurovetenskap
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- Fagius, Jan (author)
- Uppsala universitet,Neurologi
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- Mangsbo, Sara M (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
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In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 277:1-2, s. 153-159
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- In this cross-sectional study, we wanted to identify key cytokines characteristic of different stages of multiple sclerosis (MS). To this end, cerebrospinal fluid from patients with MS was investigated with a multiplexed fluorescent bead-based immunoassay. In total 43 cytokines were assessed and related to clinical and imaging data. Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. These homogenous patterns of cytokine activation do not conform to conventional Th1/Th2/Th17 responses. (C) 2014 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Cerebrospinal fluid
- Cytokines
- Magnetic resonance imaging
- Multiple sclerosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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