Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:umu-100162" > Differences in the ...

1 of 1
Previous record
Next record
To hitlist

LIBRIS Formathandbok (Information om MARC21)

Details
MARC

Fältnamn	Indikatorer	Metadata
000		06824naa a2200913 4500
001		oai:DiVA.org:umu-100162
003		SwePub
008		150224s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:52bd9e1a-b683-4679-8363-e90894aeece0
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1001622 URI
024	7	a https://doi.org/10.1016/S2213-8587(14)70146-92 DOI
024	7	a https://lup.lub.lu.se/record/46151542 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Forouhi, Nita G.4 aut
245	1 0	a Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes :b the EPIC-InterAct case-cohort study
264	1	c 2014
338		a electronic2 rdacarrier
520		a Background Conflicting evidence exists regarding the association between saturated fatty acids (SFAs) and type 2 diabetes. In this longitudinal case-cohort study, we aimed to investigate the prospective associations between objectively measured individual plasma phospholipid SFAs and incident type 2 diabetes in EPIC-InterAct participants. Methods The EPIC-InterAct case-cohort study includes 12 403 people with incident type 2 diabetes and a representative subcohort of 16 154 individuals who were selected from a cohort of 340 234 European participants with 3 . 99 million person-years of follow-up (the EPIC study). Incident type 2 diabetes was ascertained until Dec 31, 2007, by a review of several sources of evidence. Gas chromatography was used to measure the distribution of fatty acids in plasma phospholipids (mol%); samples from people with type 2 diabetes and subcohort participants were processed in a random order by centre, and laboratory staff were masked to participant characteristics. We estimated country-specific hazard ratios (HRs) for associations per SD of each SFA with incident type 2 diabetes using Prentice-weighted Cox regression, which is weighted for case-cohort sampling, and pooled our findings using random-effects meta-analysis. Findings SFAs accounted for 46% of total plasma phospholipid fatty acids. In adjusted analyses, different individual SFAs were associated with incident type 2 diabetes in opposing directions. Even-chain SFAs that were measured (14: 0 [myristic acid], 16: 0 [palmitic acid], and 18: 0 [stearic acid]) were positively associated with incident type 2 diabetes (HR [95% CI] per SD difference: myristic acid 1.15 [95% CI 1.09-1.22], palmitic acid 1.26 [1.15-1.37], and stearic acid 1.06 [1.00-1.13]). By contrast, measured odd-chain SFAs (15: 0 [pentadecanoic acid] and 17: 0 [heptadecanoic acid]) were inversely associated with incident type 2 diabetes (HR [95% CI] per 1 SD difference: 0.79 [0.73-0.85] for pentadecanoic acid and 0.67 [0.63-0.71] for heptadecanoic acid), as were measured longer-chain SFAs (20: 0 [arachidic acid], 22:0 [behenic acid], 23:0 [tricosanoic acid], and 24:0 [lignoceric acid]), with HRs ranging from 0.72 to 0.81 (95% CIs ranging between 0.61 and 0.92). Our findings were robust to a range of sensitivity analyses. Interpretation Different individual plasma phospholipid SFAs were associated with incident type 2 diabetes in opposite directions, which suggests that SFAs are not homogeneous in their effects. Our findings emphasise the importance of the recognition of subtypes of these fatty acids. An improved understanding of differences in sources of individual SFAs from dietary intake versus endogenous metabolism is needed.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Koulman, Albert4 aut
700	1	a Sharp, Stephen J.4 aut
700	1	a Imamura, Fumiaki4 aut
700	1	a Kroger, Janine4 aut
700	1	a Schulze, Matthias B.4 aut
700	1	a Crowe, Francesca L.4 aut
700	1	a Huerta, Jose Maria4 aut
700	1	a Guevara, Marcela4 aut
700	1	a Beulens, Joline W. J.4 aut
700	1	a van Woudenbergh, Geertruida J.4 aut
700	1	a Wang, Laura4 aut
700	1	a Summerhill, Keith4 aut
700	1	a Griffin, Julian L.4 aut
700	1	a Feskens, Edith J. M.4 aut
700	1	a Amiano, Pilar4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Dartois, Laureen4 aut
700	1	a Fagherazzi, Guy4 aut
700	1	a Franks, Paul W.u Lunds universitet,Umeå universitet,Medicin,Lund University, Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf
700	1	a Gonzalez, Carlos4 aut
700	1	a Jakobsen, Marianne Uhre4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Key, Timothy J.4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kuhn, Tilman4 aut
700	1	a Mattiello, Amalia4 aut
700	1	a Nilsson, Peteru Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-pni
700	1	a Overvad, Kim4 aut
700	1	a Pala, Valeria4 aut
700	1	a Palli, Domenico4 aut
700	1	a Quiros, J. Ramon4 aut
700	1	a Rolandsson, Olovu Umeå universitet,Allmänmedicin4 aut0 (Swepub:umu)olro0005
700	1	a Roswall, Nina4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Sanchez, Mara-Jose4 aut
700	1	a Slimani, Nadia4 aut
700	1	a Spijkerman, Annemieke M. W.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Tormo, Maria-Jose4 aut
700	1	a Tumino, Rosario4 aut
700	1	a van der A, Daphne L.4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Langenberg, Claudia4 aut
700	1	a Riboli, Elio4 aut
700	1	a Wareham, Nicholas J.4 aut
710	2	a Umeå universitetb Medicin4 org
773	0	t LANCET DIABETES & ENDOCRINOLOGYg 2:10, s. 810-818q 2:10<810-818x 2213-8587x 2213-8595
856	4	u https://umu.diva-portal.org/smash/get/diva2:790584/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://portal.research.lu.se/files/6549248/8147275x primaryx freey FULLTEXT
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/25107467?dopt=Abstractx freey FULLTEXT
856	4	u http://dx.doi.org/10.1016/S2213-8587(14)70146-9x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100162
856	4 8	u https://doi.org/10.1016/S2213-8587(14)70146-9
856	4 8	u https://lup.lub.lu.se/record/4615154

Find in a library

LANCET DIABETES & ENDOCRINOLOGY (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Forouhi, Nita G.; Koulman, Albert; Sharp, Stephen J ...; Imamura, Fumiaki; Kroger, Janine; Schulze, Matthia ...; show more...; Crowe, Francesca ...; Huerta, Jose Mar ...; Guevara, Marcela; Beulens, Joline ...; van Woudenbergh, ...; Wang, Laura; Summerhill, Keit ...; Griffin, Julian ...; Feskens, Edith J ...; Amiano, Pilar; Boeing, Heiner; Clavel-Chapelon, ...; Dartois, Laureen; Fagherazzi, Guy; Franks, Paul W.; Gonzalez, Carlos; Jakobsen, Marian ...; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay-Tee; Kuhn, Tilman; Mattiello, Amali ...; Nilsson, Peter; Overvad, Kim; Pala, Valeria; Palli, Domenico; Quiros, J. Ramon; Rolandsson, Olov; Roswall, Nina; Sacerdote, Carlo ...; Sanchez, Mara-Jo ...; Slimani, Nadia; Spijkerman, Anne ...; Tjonneland, Anne; Tormo, Maria-Jos ...; Tumino, Rosario; van der A, Daphn ...; van der Schouw, ...; Langenberg, Clau ...; Riboli, Elio; Wareham, Nichola ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

Articles in the publication: LANCET DIABETES ...

By the university: Umeå University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se