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Prognostic signific...
Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma
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- Andersson, Charlotta (author)
- Umeå universitet,Patologi
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Oji, Yusuke (author)
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- Ohlson, Nina (author)
- Umeå universitet,Patologi
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- Wang, Sihan (author)
- Umeå universitet,Patologi
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- Li, Xingru (author)
- Umeå universitet,Klinisk kemi
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- Ottander, Ulrika (author)
- Umeå universitet,Obstetrik och gynekologi
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- Lundin, Eva (author)
- Umeå universitet,Patologi
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Sugiyama, Haruo (author)
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- Li, Aihong (author)
- Umeå universitet,Klinisk kemi
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(creator_code:org_t)
- 2014-04-08
- 2014
- English.
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 3:4, s. 909-918
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Abstract
Subject headings
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- Ovarian carcinoma (OC) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 (WT1) is overexpressed in OCs. Therefore, it is of great interest to investigate whether WT1-specific antibody (Ab) measurements in plasma can serve as a biomarker of anti-OC response, and is of importance in relation to patient prognosis. Peripheral blood samples were obtained from a total of 103 women with ovarian tumors with median being 1 day (range 0-48 days) before operation. WT1 IgG Ab levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis of WT1 protein expression was performed on OC tissue samples. We found that low-WT1 Ab level in plasma was related to improved survival in patients diagnosed at stages III-IV and grade 3 carcinomas. Positive WT1 protein staining on OC tissue samples had a negative impact on survival in the entire cohort, both overall survival (OS) (P = 0.046) and progression-free survival (PFS) (P = 0.006), but not in the serous OC subtype. Combining WT1 IgG Ab levels and WT1 staining, patients with high-WT1 IgG Ab levels in plasma and positive WT1 protein staining in cancer tissues had shorter survival, with a significant association in PFS (P = 0.016). These results indicated that WT1 Ab measurements in plasma and WT1 staining in tissue specimens could be useful as biomarkers for patient outcome in the high-risk subtypes of OCs for postoperative individualized therapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Ovarian carcinoma
- prognosis
- WT1
- WT1 IgG antibody
Publication and Content Type
- ref (subject category)
- art (subject category)
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