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Prognostic signific...
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Andersson, CharlottaUmeå universitet,Patologi
(author)
Prognostic significance of specific anti-WT1 IgG antibody level in plasma in patients with ovarian carcinoma
- Article/chapterEnglish2014
Publisher, publication year, extent ...
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2014-04-08
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Wiley,2014
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-100163
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100163URI
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https://doi.org/10.1002/cam4.244DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Ovarian carcinoma (OC) has a poor prognosis and lack early effective screening markers. Wilm's tumor gene 1 (WT1) is overexpressed in OCs. Therefore, it is of great interest to investigate whether WT1-specific antibody (Ab) measurements in plasma can serve as a biomarker of anti-OC response, and is of importance in relation to patient prognosis. Peripheral blood samples were obtained from a total of 103 women with ovarian tumors with median being 1 day (range 0-48 days) before operation. WT1 IgG Ab levels were evaluated using enzyme-linked immunosorbent assay (ELISA). Immunohistochemical analysis of WT1 protein expression was performed on OC tissue samples. We found that low-WT1 Ab level in plasma was related to improved survival in patients diagnosed at stages III-IV and grade 3 carcinomas. Positive WT1 protein staining on OC tissue samples had a negative impact on survival in the entire cohort, both overall survival (OS) (P = 0.046) and progression-free survival (PFS) (P = 0.006), but not in the serous OC subtype. Combining WT1 IgG Ab levels and WT1 staining, patients with high-WT1 IgG Ab levels in plasma and positive WT1 protein staining in cancer tissues had shorter survival, with a significant association in PFS (P = 0.016). These results indicated that WT1 Ab measurements in plasma and WT1 staining in tissue specimens could be useful as biomarkers for patient outcome in the high-risk subtypes of OCs for postoperative individualized therapy.
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Oji, Yusuke
(author)
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Ohlson, NinaUmeå universitet,Patologi(Swepub:umu)niaohn95
(author)
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Wang, SihanUmeå universitet,Patologi(Swepub:umu)siwa0003
(author)
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Li, XingruUmeå universitet,Klinisk kemi(Swepub:umu)xili0010
(author)
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Ottander, UlrikaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)ulaotr95
(author)
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Lundin, EvaUmeå universitet,Patologi(Swepub:umu)evlu0001
(author)
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Sugiyama, Haruo
(author)
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Li, AihongUmeå universitet,Klinisk kemi(Swepub:umu)liai0001
(author)
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Umeå universitetPatologi
(creator_code:org_t)
Related titles
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In:Cancer Medicine: Wiley3:4, s. 909-9182045-7634
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