Molecular investigation of tularemia outbreaks, Spain, 1997-2008

Tularemia outbreaks occurred in northwestern Spain in 1997-1998 and 2007-2008 and affected >1,000 persons. We assessed isolates involved in these outbreaks by using pulsed-field gel electrophoresis with 2 restriction enzymes and multilocus variable number tandem repeat analysis of 16 genomic loci of Francisella tularensis, the cause of this disease. Isolates were divided into 3 pulsotypes by pulsed-field gel electrophoresis and 8 allelic profiles by multilocus variable number tandem repeat analysis. Isolates obtained from the second tularemia outbreak had the same genotypes as isolates obtained from the first outbreak. Both outbreaks were caused by genotypes of genetic subclade B.Br:FTNF002-00, which is widely distributed in countries in central and western Europe. Thus, reemergence of tularemia in Spain was not caused by the reintroduction of exotic strains, but probably by persistence of local reservoirs of infection.

Johansson, AndersUmeå universitet,Infektionssjukdomar(Swepub:umu)anjo0135 (author)
Fernández-Natal, María Isabel (author)
Martínez-Nistal, Carmen (author)
Orduña, Antonio (author)
Rodríguez-Ferri, Elías F (author)
Hernández, Marta (author)
Rodríguez-Lázaro, David (author)
Umeå universitetInfektionssjukdomar (creator_code:org_t)

In:Emerging Infectious Diseases: Centers for Disease Control and Prevention (CDC)20:5, s. 754-7611080-60401080-6059

By the author/editor: Ariza-Miguel, Ja ...; Johansson, Ander ...; Fernández-Natal, ...; Martínez-Nistal, ...; Orduña, Antonio; Rodríguez-Ferri, ...; show more...; Hernández, Marta; Rodríguez-Lázaro ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.