Search: onr:"swepub:oai:DiVA.org:umu-101625" >
Elongator, a conser...
Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes
-
- Karlsborn, Tony (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Tukenmez, Hasan (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Mahmud, A K M Firoj (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
show more...
-
- Xu, Fu (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Xu, Hao (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
- Byström, Anders S (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
-
show less...
-
(creator_code:org_t)
- 2015-01-21
- 2014
- English.
-
In: RNA Biology. - : Taylor & Francis. - 1547-6286 .- 1555-8584. ; 11:12, s. 1519-1528
- Related links:
-
https://www.tandfonl...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.4...
-
show less...
Abstract
Subject headings
Close
- Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The role of this complex has been controversial as the pleiotropic phenotypes of Elongator mutants have implicated the complex in several cellular processes. However, in yeast there is convincing evidence that the primary and probably only role of this complex is in formation of the 5-methoxycarbonylmethyl (mcm(5)) and 5-carbamoylmethyl (ncm(5)) side chains on uridines at wobble position in tRNA. In this review we summarize the cellular processes that have been linked to the Elongator complex and discuss its role in tRNA modification and regulation of translation. We also describe additional gene products essential for formation of ncm(5) and mcm(5) side chains at U-34 and their influence on Elongator activity.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- elongator complex
- KTI genes
- SIT4
- SAP genes
- tRNA wobble uridine modifications
- translation
- uveromyces lactis gamma-toxin
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database