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Comparison of plasm...
Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores : results of 4 intervention trials
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Yang, Zhenyu (author)
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Dewey, Kathryn G (author)
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Lönnerdal, Bo (author)
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- Hernell, Olle (author)
- Umeå universitet,Pediatrik
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Chaparro, Camila (author)
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Adu-Afarwuah, Seth (author)
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McLean, Erin D (author)
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Cohen, Roberta J (author)
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- Domellöf, Magnus (author)
- Umeå universitet,Pediatrik
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Allen, Lindsay H (author)
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Brown, Kenneth H (author)
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(creator_code:org_t)
- Bethseda, Md. American Society for Nutrition, 2008
- 2008
- English.
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In: American Journal of Clinical Nutrition. - Bethseda, Md. : American Society for Nutrition. - 0002-9165 .- 1938-3207. ; 87:6, s. 1892-1898
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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Abstract
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- Background: Efforts to develop global programs for the control of iron deficiency require simple, low-cost, and accurate indicators of iron status. Objective: We aimed to compare estimates of body iron (BI) stores, as calculated from either plasma ferritin concentration alone (BI-ferritin) or the ratio of plasma transferrin receptor (TfR) to ferritin (BI-TfR/ferritin). Design: Data were analyzed from 4 previously completed, randomized intervention trials that enrolled infants, schoolchildren, or pregnant women (totaln = 1189, after excluding subjects with elevated C-reactive protein). Results: The correlation coefficients between BI-ferritin and BI-TfR/ferritin were >0.95 for all studies. The kappa index ranged from 0.5 to 1.0. All of the sensitivities of BI-ferritin for identifying persons with low iron stores (defined as BI-TfR/ferritin < 0 mg/kg body wt) were >0.90. All of the specificities were >0.90 except the study of pregnant women (specificity = 0.66). The effect sizes of iron intervention trials were significantly greater for change in iron reserves estimated by BI-TfR/ferritin than by BI-ferritin in 2 studies with larger effect sizes (1.11 compared with 1.00 and 1.56 compared with 1.44, respectively; P < 0.05) and 1 study with medium effect size (0.70 compared with 0.57; P < 0.05). However, there were no significant differences between estimates of these effect sizes for 1 study with a medium effect size and 1 study with a smaller effect size (0.78 compared with 0.83 and 0.37 compared with 0.35, respectively; P > 0.2). Conclusion: Plasma ferritin concentration alone provides a good approximation of total BI reserves, as estimated by BI-TfR/ferritin, on the basis of high correlation, sensitivity, and specificity among nonpregnant persons with unelevated C-reactive protein.
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- By the author/editor
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Yang, Zhenyu
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Dewey, Kathryn G
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Lönnerdal, Bo
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Hernell, Olle
-
Chaparro, Camila
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Adu-Afarwuah, Se ...
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show more...
-
McLean, Erin D
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Cohen, Roberta J
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Domellöf, Magnus
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Allen, Lindsay H
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Brown, Kenneth H
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show less...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University