Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality.

Keyword

Cell Cycle Proteins

Chromosomes; Fungal

DNA Mutational Analysis

Enzyme Inhibitors

Fungal Proteins/*genetics

Humans

Mutation; Missense

Protein Binding

Protein Kinases/*genetics

Protein Structure; Secondary

Protein Structure; Tertiary

Protein-Serine-Threonine Kinases

Ribonucleotide Reductases/*antagonists & inhibitors

Saccharomyces cerevisiae Proteins

Solutions

Species Specificity

Suppression; Genetic

Two-Hybrid System Techniques

Publication and Content Type

ref (subject category)

art (subject category)