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Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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2015-03-05
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Springer Science and Business Media LLC,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-103555
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-103555URI
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https://doi.org/10.1038/bjc.2014.654DOI
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https://lup.lub.lu.se/record/5265186URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:131012660URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation into Cancer and nutrition, we identified 201 HCC cases after 11 years median follow-up. We calculated adjusted hazard ratios (HRs) for HCC incidence for sex-specific quintiles and per 100 g d(-1) increments of vegetable/fruit intakes. Results: Higher vegetable intake was associated with a statistically significant, monotonic reduction of HCC risk: HR (100 g d(-1) increment): 0.83; 95% CI: 0.71-0.98. This association was consistent in sensitivity analyses with no apparent heterogeneity across strata of HCC risk factors. Fruit intake was not associated with HCC incidence: HR (100 g d(-1) increment): 1.01; 95% CI: 0.92-1.11. Conclusions: Vegetable, but not fruit, intake is associated with lower HCC risk with no evidence for heterogeneity of this association in strata of important HCC risk factors. Mechanistic studies should clarify pathways underlying this association. Given that HCC prognosis is poor and that vegetables are practically universally accessible, our results may be important, especially for those at high risk for the disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lagiou, P.
(author)
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Jenab, M.
(author)
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Aleksandrova, K.
(author)
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Fedirko, V.
(author)
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Trichopoulos, D.
(author)
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Overvad, K.
(author)
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Tjonneland, A.
(author)
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Olsen, A.
(author)
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Clavel-Chapelon, F.
(author)
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Boutron-Ruault, M-C
(author)
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Kvaskoff, M.
(author)
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Katzke, V. A.
(author)
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Kuehn, T.
(author)
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Boeing, H.
(author)
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Noethlings, U.
(author)
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Palli, D.
(author)
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Sieri, S.
(author)
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Panico, S.
(author)
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Tumino, R.
(author)
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Naccarati, A.
(author)
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Bueno-de-Mesquita, H. B(As)
(author)
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Peeters, P. H. M.
(author)
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Weiderpass, E.Karolinska Institutet
(author)
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Skeie, G.
(author)
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Quiros, J. R.
(author)
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Agudo, A.
(author)
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Chirlaque, M-D
(author)
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Sanchez, M-J
(author)
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Ardanaz, E.
(author)
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Dorronsoro, M.
(author)
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Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)medf-upe
(author)
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Nilsson, Lena MariaUmeå universitet,Näringsforskning,Arktiskt centrum vid Umeå universitet (Arcum)(Swepub:umu)leni0002
(author)
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Wennberg, MariaUmeå universitet,Näringsforskning(Swepub:umu)mawe0024
(author)
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Khaw, K-T
(author)
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Wareham, N.
(author)
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Key, T. J.
(author)
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Travis, R. C.
(author)
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Ferrari, P.
(author)
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Stepien, M.
(author)
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Duarte-Salles, T.
(author)
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Norat, T.
(author)
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Murphy, N.
(author)
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Riboli, E.
(author)
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Trichopoulou, A.
(author)
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Karolinska InstitutetDiabetes - kardiovaskulär sjukdom
(creator_code:org_t)
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In:British Journal of Cancer: Springer Science and Business Media LLC112:7, s. 1273-12820007-09201532-1827
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Bamia, C.
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Lagiou, P.
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Jenab, M.
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Aleksandrova, K.
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Fedirko, V.
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Trichopoulos, D.
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Overvad, K.
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Tjonneland, A.
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Olsen, A.
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Kvaskoff, M.
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Katzke, V. A.
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Kuehn, T.
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Boeing, H.
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Noethlings, U.
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Palli, D.
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Sieri, S.
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Panico, S.
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Tumino, R.
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Naccarati, A.
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Bueno-de-Mesquit ...
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Peeters, P. H. M ...
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Weiderpass, E.
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Skeie, G.
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Quiros, J. R.
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Agudo, A.
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Chirlaque, M-D
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Sanchez, M-J
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Ardanaz, E.
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Dorronsoro, M.
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Ericson, Ulrika
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Nilsson, Lena Ma ...
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Wennberg, Maria
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Khaw, K-T
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Wareham, N.
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Key, T. J.
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Travis, R. C.
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Ferrari, P.
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Stepien, M.
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Duarte-Salles, T ...
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Norat, T.
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Murphy, N.
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Riboli, E.
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Trichopoulou, A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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British Journal ...
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Umeå University
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Lund University
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Karolinska Institutet