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Pathways related to...
Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China
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- Li, Chunyan (author)
- 1Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China; Institute of Health Education of Xi’an, Xi’an, China
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- Wang, Weizhuo (author)
- Department of Orthopedics Surgery, Second Hospital, Xi’an Jiaotong University, Xi’an, China
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- Guo, Xiong (author)
- Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China
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- Zhang, Feng (author)
- Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China
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- Ma, Weijuan (author)
- Faculty of Public Health, Medical College of Xi’an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Ministry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi’an, China
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- Zhang, Yingang (author)
- Department of Orthopedics Surgery, First Hospital, Xi’an Jiaotong University, Xi’an, China
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- Li, Youfen (author)
- School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, China
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- Bai, Yidong (author)
- Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA
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- Lammi, Mikko, 1961- (author)
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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(creator_code:org_t)
- 2012-12-12
- 2012
- English.
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In: Science China Life Sciences. - : Springer Science+Business Media B.V.. - 1674-7305 .- 1869-1889. ; 55:12, s. 1057-1063
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Abstract
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- n this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Kashin-Beck disease
- Mitochondrial dysfunction
- Ingenuity pathway analysis
- Microarray
- Cartilage
- genetik
- Genetics
- ortopedi
- Orthopaedics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Chunyan
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Wang, Weizhuo
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Guo, Xiong
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Zhang, Feng
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Ma, Weijuan
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Zhang, Yingang
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Li, Youfen
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Bai, Yidong
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Lammi, Mikko, 19 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Science China Li ...
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Umeå University