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- Lindvall, PeterUmeå universitet,Klinisk neurovetenskap (author)
Hypofractionated stereotactic radiotherapy in medium-sized to large arteriovenous malformations
- Article/chapterEnglish2015
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- Elsevier BV,2015
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:umu-106122
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106122URI
- https://doi.org/10.1016/j.jocn.2014.12.015DOI
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- Language:English
- Summary in:English
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- We have reviewed treatment results in terms of obliteration and complications in 24 patients with medium to large sized cerebral arteriovenous malformations (AVMs) (mean volume 18.5 +/- 8.9 cm(3); range: 10-42) treated with hypofractionated stereotactic radiotherapy (HSRT). AVMs are congenital lesions associated with a high morbidity and mortality. Radiosurgery is one option for treatment. However, in larger AVMs with volumes exceeding 10 cm(3) obliteration rates are less favourable and radiation induced complications more frequent. For larger AVMs, volume-staged radiosurgery is one option while another option may be the use of HSRT. Patients were treated with 6-7 Gy in five fractions to a total dose of 30-35 Gy (mean total dose 32.9 +/- 1.6 Gy [standard error of the mean]). Sixteen patients (69.6%) showed obliteration after a mean time of 35.2 +/- 14.8 months (range: 24-60). Only one patient (4.2%) experienced symptomatic radionecrosis. Our treatment with HSRT seems safe and efficient for treatment of medium to large sized AVMs. Treatment results seem to be in line with volume-staged radiosurgery and may be an alternative for AVMs not suitable for single fraction radiosurgery.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Arteriovenous malformations
- Linear accelerator
- Radiosurgery
- Treatment results
Added entries (persons, corporate bodies, meetings, titles ...)
- Grayson, DavidUmeå universitet,Klinisk neurovetenskap (author)
- Bergström, PerUmeå universitet,Onkologi(Swepub:umu)pebe0049 (author)
- Bergenheim, A. TommyUmeå universitet,Klinisk neurovetenskap(Swepub:umu)tobe0004 (author)
- Umeå universitetKlinisk neurovetenskap (creator_code:org_t)
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- In:Journal of clinical neuroscience: Elsevier BV22:6, s. 955-9580967-58681532-2653
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