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Expression of p16 i...
Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1
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- Sgaramella, Nicola (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Naples, Italy
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- Coates, P. J. (author)
- Dundee, U.K.
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- Strindlund, K. (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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- Loljung, Lotta (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap,Foggia, Italy
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- Colella, G. (author)
- Naples, Italy
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- Laurell, Göran (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar,Uppsala, Sweden
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- Rossiello, R. (author)
- Naples, Italy,Brno, Czech Republic; Paris, France
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- Muzio, L. L. (author)
- Foggia, Italy
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- Loizou, Christos (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Tartaro, G. (author)
- Naples, Italy
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- Olofsson, Katarina (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Danielsson, Karin (author)
- Umeå universitet,Institutionen för odontologi
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- Fåhraeus, R. (author)
- Brno, Czech Republic; Paris, France
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- Nylander, Karin (author)
- Umeå universitet,Institutionen för medicinsk biovetenskap
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(creator_code:org_t)
- 2015-06-09
- 2015
- English.
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In: British Journal of Cancer. - : Nature Publishing Group. - 0007-0920 .- 1532-1827. ; 113:2, s. 321-326
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Abstract
Subject headings
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- Background: Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. Methods: Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. Results: No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC. Conclusion: Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged <= 40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- squamous cell carcinoma
- tongue
- HPV
- p16
- syndecan-1
- TRE S
- 1995
- JOURNAL OF CLINICAL PATHOLOGY
- V48
- P876 galdi M.
- 2012
- JOURNAL OF ORAL PATHOLOGY & MEDICINE
- V41
- P16 aturvedi Anil K.
- 2011
- JOURNAL OF CLINICAL ONCOLOGY
- V29
- P4294
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sgaramella, Nico ...
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Coates, P. J.
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Strindlund, K.
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Loljung, Lotta
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Colella, G.
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Laurell, Göran
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show more...
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Rossiello, R.
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Muzio, L. L.
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Loizou, Christos
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Tartaro, G.
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Olofsson, Katari ...
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Danielsson, Kari ...
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Fåhraeus, R.
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Nylander, Karin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Otorhinolaryngol ...
- Articles in the publication
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British Journal ...
- By the university
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Umeå University
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Uppsala University