Search: onr:"swepub:oai:DiVA.org:umu-106963" >
Function and regula...
Function and regulation of let-7 family microRNAs
-
Su, Jen-Liang (author)
-
Chen, Pai-Sheng (author)
-
- Johansson, Gunnar (author)
- Institute of Toxicology, National Taiwan University, No. 1, Section 1, Jen-Ai Road, Taipei, 100, Taiwan
-
show more...
-
Kuo, Min-Liang (author)
-
show less...
-
Institute of Toxicology, National Taiwan University, No 1, Section 1, Jen-Ai Road, Taipei, 100, Taiwan (creator_code:org_t)
- Bentham, 2012
- 2012
- English.
-
In: MicroRNA (Shāriqah, United Arab Emirates). - : Bentham. - 2211-5366 .- 2211-5374. ; 1:1, s. 34-39
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.2...
-
show less...
Abstract
Subject headings
Close
- MicroRNAs (miRNAs) are a group of small noncoding RNAs capable of regulating specific gene expression. Let-7 miRNA was first discovered in Caenorhabditis elegans and it is highly conserved in human tissues. The human let- 7 family of miRNA contains 12 members of miRNA. Today, these members have become the most studied miRNAs and they have attracted attention of researchers in various fields, such as development, stem cell biology, aging, and metabolism. Furthermore, there is a large body of evidence linking the loss of let-7 expression and the development of poorly differentiated, aggressive cancers. In addition to the canonical biogenesis pathway, let-7 has been found to be regulated by protein factors, such as RNA binding proteins previously identified as regulators of protein-coding mRNAs. Moreover, the direct interaction between miRNAs has recently been identified as a novel pathway to control let-7 expression. In this review, we discuss the multifaceted roles of let-7 and provide an overview of its regulation at multiple levels.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database