Search: onr:"swepub:oai:DiVA.org:umu-107155" >
A Transgenic Drosop...
A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo
-
Shirinian, Margret (author)
-
Kambris, Zakaria (author)
-
Hamadeh, Lama (author)
-
show more...
-
- Grabbe, Caroline (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
-
Journo, Chloe (author)
-
Mahieux, Renaud (author)
-
Bazarbachi, Ali (author)
-
show less...
-
(creator_code:org_t)
- 2015
- 2015
- English.
-
In: Journal of Virology. - 0022-538X .- 1098-5514. ; 89:15, s. 8092-8095
- Related links:
-
https://umu.diva-por... (primary) (Raw object)
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-kappa B. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKK gamma/NEMO), thus validating this new in vivo model.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database