Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage

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Sjöberg, Rickard L.Umeå universitet,Klinisk neurovetenskap (author)

Blood Metabolomic Predictors of 1-Year Outcome in Subarachnoid Hemorrhage

Article/chapterEnglish2015

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2015-02-10
Springer,2015
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LIBRIS-ID:oai:DiVA.org:umu-109362
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-109362URI
https://doi.org/10.1007/s12028-014-0089-2DOI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Delayed neurological deficit (DND) is the most important cause of morbidity and mortality in patients with subarachnoid hemorrhage (SAH) whose aneurysms have been secured. However, the methods currently used to predict the development of DND, such as trans-cranial Doppler or levels biochemical markers in blood and cerebrospinal fluid are not very accurate. Venous blood was drawn from 50 patients with SAH, admitted to the neurosurgical department UmeAyen University Hospital, at day 1-3 and day 7 after the bleed. The clinical status of the patients was followed up approximately 1 year after this episode and classified according to the Glasgow Outcome Score (GOS). Results showed considerable differences in blood metabolomic patterns between day 1-3 and 7 after the hemorrhage. Fifty-six out of 98 metabolites could be identified from our in-house library and 17 of these metabolites changed significantly from day 1-3 to 7 after the bleed. One of these, myo-inositol, was predictive of clinical outcome even after correction for multiple testing. An estimation of the diagnostic accuracy of high levels of this substance in predicting good outcome (GOS 4-5) yielded a sensitivity of .763 and a specificity of .5 at the optimal cut off point. SAH is an event with a profound effect on blood metabolomics profiles. Myo-inositol might be an interesting compound for future study to focus on in the search for metabolic markers in venous blood of delayed neurological deterioration in SAH patients.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Delayed neurological deficit
Myo-inositol
Metabolomics
Subarachnoid hemorrhage
Vasospasm
nous blood

Added entries (persons, corporate bodies, meetings, titles ...)

Bergenheim, TommyUmeå universitet,Klinisk neurovetenskap(Swepub:umu)tobe0004 (author)
Mörén, Lina,1985-Umeå universitet,Kemiska institutionen,Computational Life Science Cluster, Umeå University, Umeå, Sweden(Swepub:umu)liamen04 (author)
Antti, Henrik,1970-Umeå universitet,Kemiska institutionen,Computational Life Science Cluster, Umeå University, Umeå, Sweden(Swepub:umu)hean0004 (author)
Lindgren, Cecilia,1958-Umeå universitet,Anestesiologi och intensivvård(Swepub:umu)celi0010 (author)
Naredi, SilvanaUmeå universitet,Anestesiologi och intensivvård(Swepub:umu)nasi0001 (author)
Lindvall, PeterUmeå universitet,Klinisk neurovetenskap(Swepub:umu)peli0055 (author)
Umeå universitetKlinisk neurovetenskap (creator_code:org_t)

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In:Neurocritical Care: Springer23:2, s. 225-2321541-69331556-0961

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